Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/YoeB-YefM |
| Location | 1139954..1140456 | Replicon | chromosome |
| Accession | NZ_CP060946 | ||
| Organism | Escherichia coli O157:H7 str. EC10 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | U9YDH0 |
| Locus tag | H9197_RS05655 | Protein ID | WP_000767829.1 |
| Coordinates | 1139954..1140208 (-) | Length | 85 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S1Q063 |
| Locus tag | H9197_RS05660 | Protein ID | WP_001259255.1 |
| Coordinates | 1140205..1140456 (-) | Length | 84 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9197_RS05625 (1134969) | 1134969..1135196 | - | 228 | WP_000985280.1 | thiosulfate utilization sulfurtransferase TsuB/YeeD | - |
| H9197_RS05630 (1135210) | 1135210..1136268 | - | 1059 | WP_000492315.1 | thiosulfate utilization transporter TsuA/YeeE | - |
| H9197_RS05635 (1136447) | 1136447..1137805 | - | 1359 | WP_000019197.1 | putrescine/proton symporter PlaP | - |
| H9197_RS05640 (1137795) | 1137795..1137857 | - | 63 | WP_010723108.1 | membrane protein YoeI | - |
| H9197_RS05645 (1138072) | 1138072..1139001 | - | 930 | WP_000803351.1 | LysR substrate-binding domain-containing protein | - |
| H9197_RS05650 (1139047) | 1139047..1139871 | - | 825 | WP_000754749.1 | SDR family oxidoreductase | - |
| H9197_RS05655 (1139954) | 1139954..1140208 | - | 255 | WP_000767829.1 | type II toxin-antitoxin system mRNA interferase toxin YoeB | Toxin |
| H9197_RS05660 (1140205) | 1140205..1140456 | - | 252 | WP_001259255.1 | YoeB-YefM toxin-antitoxin system antitoxin YefM | Antitoxin |
| H9197_RS05665 (1140739) | 1140739..1140789 | + | 51 | WP_001364200.1 | his operon leader peptide | - |
| H9197_RS05670 (1140935) | 1140935..1141834 | + | 900 | WP_000131776.1 | ATP phosphoribosyltransferase | - |
| H9197_RS05675 (1141840) | 1141840..1143144 | + | 1305 | WP_001515511.1 | histidinol dehydrogenase | - |
| H9197_RS05680 (1143141) | 1143141..1144211 | + | 1071 | WP_000108940.1 | histidinol-phosphate transaminase | - |
| H9197_RS05685 (1144211) | 1144211..1145278 | + | 1068 | WP_000080085.1 | bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 85 a.a. Molecular weight: 10183.58 Da Isoelectric Point: 8.0353
>T171659 WP_000767829.1 NZ_CP060946:c1140208-1139954 [Escherichia coli O157:H7 str. EC10]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY
Download Length: 255 bp
>T171659 NZ_CP078009:2536055-2536336 [Pseudomonas aeruginosa]
ATGACCTATAAGCTCGAATTCCTGCCCTCGGCGCTGAAGGAGTGGGAGAAGCTGGGTCATACGCTGCGTGAACAGGCAAA
GAAAAAGCTTCGCGAGCGATTGGAAGCACCAAAGGTACAGACTGATGCCCTCAGGGATCTGCCTGGGCACTACAAAATCA
AGCTCCGAACAGCAGGCTATCGATTGGTCTACCGGGTCGAAGATGATCGAGTGGTTGTAGTGGTGGTCGCAGTTGGCAAA
CGTGAGCGAGGTGCTGCTTACAAGGCAGCAGCTAAGCGTTAG
ATGACCTATAAGCTCGAATTCCTGCCCTCGGCGCTGAAGGAGTGGGAGAAGCTGGGTCATACGCTGCGTGAACAGGCAAA
GAAAAAGCTTCGCGAGCGATTGGAAGCACCAAAGGTACAGACTGATGCCCTCAGGGATCTGCCTGGGCACTACAAAATCA
AGCTCCGAACAGCAGGCTATCGATTGGTCTACCGGGTCGAAGATGATCGAGTGGTTGTAGTGGTGGTCGCAGTTGGCAAA
CGTGAGCGAGGTGCTGCTTACAAGGCAGCAGCTAAGCGTTAG
Antitoxin
Download Length: 84 a.a. Molecular weight: 9307.58 Da Isoelectric Point: 4.7954
>AT171659 WP_001259255.1 NZ_CP060946:c1140456-1140205 [Escherichia coli O157:H7 str. EC10]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE
Download Length: 252 bp
>AT171659 NZ_CP078009:2535820-2536065 [Pseudomonas aeruginosa]
ATGCAGAGTGTTTTGGCCGACGTTGCCGTGAGCGTTTCTGAGCTGAAGAAAAACCCCACTGGAGTCATGGCTGGTGCCGG
AGGCATGCCGGTCGCCGTTCTTAATCATAACCGCGTGATGGGGTACATGGTGCCTGCCGAGCTGTACGAGCAGATGCTGG
ACCGTCTGGACGATCTGGATCTAATCGATGTCGTTAACGCACGTTCCGGTGAGAAGGGTGTGCCGGTGAACCTGGATGAC
CTATAA
ATGCAGAGTGTTTTGGCCGACGTTGCCGTGAGCGTTTCTGAGCTGAAGAAAAACCCCACTGGAGTCATGGCTGGTGCCGG
AGGCATGCCGGTCGCCGTTCTTAATCATAACCGCGTGATGGGGTACATGGTGCCTGCCGAGCTGTACGAGCAGATGCTGG
ACCGTCTGGACGATCTGGATCTAATCGATGTCGTTAACGCACGTTCCGGTGAGAAGGGTGTGCCGGTGAACCTGGATGAC
CTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|