Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 1372259..1372952 Replicon chromosome
Accession NZ_CP060938
Organism Escherichia coli strain EC11

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag H9198_RS06620 Protein ID WP_000415584.1
Coordinates 1372259..1372555 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H9198_RS06625 Protein ID WP_000650107.1
Coordinates 1372557..1372952 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9198_RS06585 (1367347) 1367347..1367661 - 315 WP_000958598.1 putative quinol monooxygenase -
H9198_RS06590 (1367692) 1367692..1368273 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
H9198_RS06595 (1368592) 1368592..1368924 + 333 WP_000917685.1 DUF2645 family protein -
H9198_RS06600 (1368970) 1368970..1370319 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
H9198_RS06605 (1370316) 1370316..1370975 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
H9198_RS06610 (1371127) 1371127..1371519 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H9198_RS06615 (1371572) 1371572..1372054 + 483 WP_000183505.1 GyrI-like domain-containing protein -
H9198_RS06620 (1372259) 1372259..1372555 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
H9198_RS06625 (1372557) 1372557..1372952 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H9198_RS06630 (1373085) 1373085..1374692 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
H9198_RS06635 (1374830) 1374830..1377088 + 2259 WP_001281846.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T171624 WP_000415584.1 NZ_CP060938:1372259-1372555 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T171624 NZ_CP078002:c176389-176108 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACACCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCTCTGAAAGCCGTTCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTAGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGACCCTGGAGCGCTGGCCGTTCAGCGCCCCGTTTCGGGTTAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT171624 WP_000650107.1 NZ_CP060938:1372557-1372952 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT171624 NZ_CP078002:c176613-176386 [Pseudomonas aeruginosa]
ATGAGCACCGTAGTCTCGTTCCGCGCCGATGACGCCCTGGTCGCGGCCCTCGACGAACTGGCCCGCGCCACCCACCGCGA
CCGCCCCTACCACCTGCGGCAGGCGCTCGCGCAGTACCTGGAAAGGCAGCAGTGGCAGGTCGCTGCCATCGATGAAGGCT
TGGCCGATGCCAATGCCGGTCGCCTGCTGGAACACATCGAGATCGAGAAGCGCTGGGGGCTGCAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References