Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 120263..120689 | Replicon | plasmid pEC13-2 |
| Accession | NZ_CP060929 | ||
| Organism | Escherichia coli strain EC13 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | H9200_RS23610 | Protein ID | WP_001372321.1 |
| Coordinates | 120263..120388 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 120465..120689 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9200_RS23570 (115637) | 115637..116326 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| H9200_RS23575 (116513) | 116513..116896 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| H9200_RS23580 (117217) | 117217..117819 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| H9200_RS23585 (118116) | 118116..118937 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| H9200_RS23590 (119055) | 119055..119342 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| H9200_RS23595 (119367) | 119367..119573 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| H9200_RS23600 (119643) | 119643..119815 | + | 173 | Protein_134 | hypothetical protein | - |
| H9200_RS23605 (119813) | 119813..120043 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| H9200_RS23610 (120263) | 120263..120388 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| H9200_RS23615 (120330) | 120330..120479 | - | 150 | Protein_137 | plasmid maintenance protein Mok | - |
| - (120465) | 120465..120689 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (120465) | 120465..120689 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (120465) | 120465..120689 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (120465) | 120465..120689 | - | 225 | NuclAT_0 | - | Antitoxin |
| H9200_RS23620 (120501) | 120501..120689 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| H9200_RS23625 (120658) | 120658..121420 | - | 763 | Protein_139 | plasmid SOS inhibition protein A | - |
| H9200_RS23630 (121417) | 121417..121851 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| H9200_RS23635 (121906) | 121906..122103 | - | 198 | Protein_141 | hypothetical protein | - |
| H9200_RS23640 (122131) | 122131..122364 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| H9200_RS23645 (122432) | 122432..122971 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| H9200_RS23650 (122997) | 122997..123203 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| H9200_RS23655 (123273) | 123273..123353 | + | 81 | Protein_145 | hypothetical protein | - |
| H9200_RS23660 (123536) | 123536..123705 | - | 170 | Protein_146 | hypothetical protein | - |
| H9200_RS23665 (124342) | 124342..125313 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-14 / fosA3 / aac(3)-IVa / sul2 / floR / dfrA17 / oqxB / oqxA / sitABCD | iroB / iroC / iroD / iroE / iroN / iutA / iucD / iucC / iucB / iucA | 1..145694 | 145694 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T171586 WP_001372321.1 NZ_CP060929:c120388-120263 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T171586 NZ_CP077985:3652203-3652781 [Pseudomonas aeruginosa]
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGTTCGGCGCGACGCCTAG
ATGTCCCTCGAACTGCTGAGCAACCGCCTCGAATTCCTCCGCGAAGCCGAACGCCTGAAAGACGTCCTGCGCTCCGCGCA
CACCTCCTCCGGCCGCCCGGAAAGCACCGCCGAACATAGCTGGCGGCTGTGCCTGATGGCACTGGCCTTCGAGGACCAAC
TGGCCGGCCTGGACCTCGGCAAGGTCCTGCGCATGTGCGTGGTCCACGACCTCGGCGAAGCGATCCACGGCGACATCCCC
GCCGTCGAGCAGGCCGCGCACCCGGACAAAGGCGAACAGGAACGCGCCGACCTGTTGCAGCTGACCCGTCACCTCGACGC
GCCGCTGCGCGACCGCCTGCTCGCCCTGTGGGACGAATACGAGCGCGGCGAGTCCGCCGAAGCCCTGGCAGTGAAGGCCC
TGGACAAGCTGGAAACCCTGCTCCAGCACACCCAGGGCGACAATCCGGCGGACTTCGACTATGCCTTCAACCTCGACTAC
GGCCGTCGCTATACCGACCGCGCACCGCTGTTCAAGACCCTGCGCGAGCTACTCGACGCCAGGACCCGACAGCGCCTCGC
AGTTCGGCGCGACGCCTAG
Antitoxin
Download Length: 225 bp
>AT171586 NZ_CP060929:c120689-120465 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
