Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 133722..134148 | Replicon | plasmid pEC14-2 |
| Accession | NZ_CP060925 | ||
| Organism | Escherichia coli strain EC14 | ||
Toxin (Protein)
| Gene name | hok | Uniprot ID | - |
| Locus tag | H9201_RS24135 | Protein ID | WP_001372321.1 |
| Coordinates | 133722..133847 (-) | Length | 42 a.a. |
Antitoxin (RNA)
| Gene name | sok | ||
| Locus tag | - | ||
| Coordinates | 133924..134148 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9201_RS24095 (129096) | 129096..129785 | - | 690 | WP_000283385.1 | conjugal transfer transcriptional regulator TraJ | - |
| H9201_RS24100 (129972) | 129972..130355 | - | 384 | WP_001151524.1 | conjugal transfer relaxosome DNA-binding protein TraM | - |
| H9201_RS24105 (130676) | 130676..131278 | + | 603 | WP_000243712.1 | transglycosylase SLT domain-containing protein | - |
| H9201_RS24110 (131575) | 131575..132396 | - | 822 | WP_001234426.1 | DUF932 domain-containing protein | - |
| H9201_RS24115 (132514) | 132514..132801 | - | 288 | WP_000107535.1 | hypothetical protein | - |
| H9201_RS24120 (132826) | 132826..133032 | - | 207 | WP_000547968.1 | hypothetical protein | - |
| H9201_RS24125 (133102) | 133102..133274 | + | 173 | Protein_160 | hypothetical protein | - |
| H9201_RS24130 (133272) | 133272..133502 | - | 231 | WP_071586998.1 | hypothetical protein | - |
| H9201_RS24135 (133722) | 133722..133847 | - | 126 | WP_001372321.1 | type I toxin-antitoxin system Hok family toxin | Toxin |
| H9201_RS24140 (133789) | 133789..133938 | - | 150 | Protein_163 | plasmid maintenance protein Mok | - |
| - (133924) | 133924..134148 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (133924) | 133924..134148 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (133924) | 133924..134148 | - | 225 | NuclAT_0 | - | Antitoxin |
| - (133924) | 133924..134148 | - | 225 | NuclAT_0 | - | Antitoxin |
| H9201_RS24145 (133960) | 133960..134148 | + | 189 | WP_001299721.1 | hypothetical protein | - |
| H9201_RS24150 (134117) | 134117..134879 | - | 763 | Protein_165 | plasmid SOS inhibition protein A | - |
| H9201_RS24155 (134876) | 134876..135310 | - | 435 | WP_000845936.1 | conjugation system SOS inhibitor PsiB | - |
| H9201_RS24160 (135365) | 135365..135562 | - | 198 | Protein_167 | hypothetical protein | - |
| H9201_RS24165 (135590) | 135590..135823 | - | 234 | WP_000005987.1 | DUF905 family protein | - |
| H9201_RS24170 (135891) | 135891..136430 | - | 540 | WP_000290840.1 | single-stranded DNA-binding protein | - |
| H9201_RS24175 (136456) | 136456..136662 | - | 207 | WP_000275856.1 | hypothetical protein | - |
| H9201_RS24180 (136732) | 136732..136812 | + | 81 | Protein_171 | hypothetical protein | - |
| H9201_RS24185 (136995) | 136995..137164 | - | 170 | Protein_172 | hypothetical protein | - |
| H9201_RS24190 (137758) | 137758..138729 | - | 972 | WP_000817028.1 | ParB/RepB/Spo0J family plasmid partition protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | tet(A) / dfrA14 / aac(3)-IIa / sitABCD | iutA / iucD / iucC / iucB / iucA | 1..159110 | 159110 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 42 a.a. Molecular weight: 4780.69 Da Isoelectric Point: 8.5110
>T171554 WP_001372321.1 NZ_CP060925:c133847-133722 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
VLIVCLTLLIFTYLTRKSLCEIRYRDGHREVAAFMAYESGK
Download Length: 126 bp
>T171554 NZ_CP077969:c2953414-2953007 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA
Antitoxin
Download Length: 225 bp
>AT171554 NZ_CP060925:c134148-133924 [Escherichia coli]
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
TCACACGGATTTCCCGTGAACGGTCTGAATGAGCGGATTATTTTCAGGGAAAGTGAGTGTGGTCAGCGTGCAGGTATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAAGA
AGATAGCCCCGTAGTAAGTTAATTTTCATTAACCACCACGAGGCATCCCTATGTCTAGTCCACAT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
