Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 4041922..4042463 Replicon chromosome
Accession NZ_CP060919
Organism Escherichia coli strain EC15

Toxin (Protein)


Gene name yafQ Uniprot ID E9TC49
Locus tag H9202_RS19865 Protein ID WP_000615982.1
Coordinates 4042185..4042463 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID S1EWQ0
Locus tag H9202_RS19860 Protein ID WP_000729704.1
Coordinates 4041922..4042182 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9202_RS19835 (4036958) 4036958..4038097 + 1140 WP_000785662.1 flagellar type III secretion system protein FlhB -
H9202_RS19840 (4038081) 4038081..4040174 + 2094 WP_001140806.1 flagellar biosynthesis protein FlhA -
H9202_RS19845 (4040279) 4040279..4040557 + 279 WP_000598760.1 type II toxin-antitoxin system HicA family toxin -
H9202_RS19850 (4040550) 4040550..4040906 + 357 WP_001030484.1 type II toxin-antitoxin system HicB family antitoxin -
H9202_RS19855 (4040963) 4040963..4041736 - 774 WP_000543899.1 C40 family peptidase -
H9202_RS19860 (4041922) 4041922..4042182 + 261 WP_000729704.1 type II toxin-antitoxin system antitoxin DinJ Antitoxin
H9202_RS19865 (4042185) 4042185..4042463 + 279 WP_000615982.1 type II toxin-antitoxin system mRNA interferase toxin YafQ Toxin
H9202_RS19870 (4042619) 4042619..4043359 + 741 WP_001225679.1 peptidoglycan meso-diaminopimelic acid protein amidase -
H9202_RS19875 (4043330) 4043330..4044097 - 768 WP_000333380.1 class II glutamine amidotransferase -
H9202_RS19880 (4044303) 4044303..4044881 - 579 WP_000284050.1 D-sedoheptulose 7-phosphate isomerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10816.59 Da        Isoelectric Point: 10.0702

>T171514 WP_000615982.1 NZ_CP060919:4042185-4042463 [Escherichia coli]
MIQRDIEYSGQFSKDVKVAQKRHKDMNKLKYLMTLLINNTLPLPAVYKDHPLQGSWKGYRDAHVEPDWILIYKLTDKLLR
FERTGTHAALFG

Download         Length: 279 bp

>T171514 NZ_CP077936:c2299094-2298990 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGATTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9391.77 Da        Isoelectric Point: 5.0758

>AT171514 WP_000729704.1 NZ_CP060919:4041922-4042182 [Escherichia coli]
MAANAFVRARIDEDLKNQAADVLAGMGLTISDLVRITLTKVAREKALPFDLREPNQLTIQSIKNSEAGVDVHKAKDADDL
FDKLGI

Download         Length: 261 bp

>AT171514 NZ_CP077936:2298897-2298935 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 4ML0
AlphaFold DB A0A0E0Y6Z6

References