Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 43439..43693 | Replicon | plasmid pEC19-2 |
| Accession | NZ_CP060909 | ||
| Organism | Escherichia coli strain EC19 | ||
Toxin (Protein)
| Gene name | srnB | Uniprot ID | G9G1E3 |
| Locus tag | H9204_RS23775 | Protein ID | WP_001312851.1 |
| Coordinates | 43439..43588 (-) | Length | 50 a.a. |
Antitoxin (RNA)
| Gene name | srnC | ||
| Locus tag | - | ||
| Coordinates | 43632..43693 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9204_RS23745 (38686) | 38686..39597 | - | 912 | WP_000440183.1 | carbamate kinase | - |
| H9204_RS23750 (39608) | 39608..40828 | - | 1221 | WP_000410951.1 | arginine deiminase | - |
| H9204_RS23755 (41535) | 41535..42149 | + | 615 | Protein_47 | VENN motif pre-toxin domain-containing protein | - |
| H9204_RS23760 (42149) | 42149..42595 | - | 447 | Protein_48 | plasmid replication initiator RepA | - |
| H9204_RS23765 (42588) | 42588..42662 | - | 75 | WP_032336874.1 | RepA leader peptide Tap | - |
| H9204_RS23770 (42898) | 42898..43155 | - | 258 | WP_000083833.1 | replication regulatory protein RepA | - |
| H9204_RS23775 (43439) | 43439..43588 | - | 150 | WP_001312851.1 | Hok/Gef family protein | Toxin |
| - (43632) | 43632..43693 | + | 62 | NuclAT_0 | - | Antitoxin |
| - (43632) | 43632..43693 | + | 62 | NuclAT_0 | - | Antitoxin |
| - (43632) | 43632..43693 | + | 62 | NuclAT_0 | - | Antitoxin |
| - (43632) | 43632..43693 | + | 62 | NuclAT_0 | - | Antitoxin |
| H9204_RS23780 (43832) | 43832..44014 | - | 183 | WP_000968309.1 | hypothetical protein | - |
| H9204_RS23785 (44115) | 44115..44731 | + | 617 | Protein_53 | IS1-like element IS1A family transposase | - |
| H9204_RS23790 (44769) | 44769..46340 | - | 1572 | WP_023149734.1 | IS66-like element ISCro1 family transposase | - |
| H9204_RS23795 (46360) | 46360..46707 | - | 348 | WP_000624622.1 | IS66 family insertion sequence element accessory protein TnpB | - |
| H9204_RS23800 (46707) | 46707..47384 | - | 678 | WP_001339397.1 | IS66-like element accessory protein TnpA | - |
| H9204_RS23805 (47439) | 47439..47528 | + | 90 | Protein_57 | IS1 family transposase | - |
| H9204_RS23810 (47829) | 47829..48041 | - | 213 | WP_005012601.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | blaOXA-1 / aac(6')-Ib-cr / tet(A) / sitABCD | iutA / iucD / iucC / iucB / iucA | 1..88659 | 88659 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 50 a.a. Molecular weight: 5542.67 Da Isoelectric Point: 8.7678
>T171453 WP_001312851.1 NZ_CP060909:c43588-43439 [Escherichia coli]
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
MTKYALIGLLAVCATVLCFSLIFRERLCELNIHRGNTVVQVTLAYEARK
Download Length: 150 bp
>T171453 NZ_CP077924:225008-225115 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA
Antitoxin
Download Length: 62 bp
>AT171453 NZ_CP060909:43632-43693 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
