Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 777288..777981 Replicon chromosome
Accession NZ_CP060908
Organism Escherichia coli strain EC19

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag H9204_RS03770 Protein ID WP_000415585.1
Coordinates 777288..777584 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H9204_RS03775 Protein ID WP_000650107.1
Coordinates 777586..777981 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9204_RS03735 (772422) 772422..772901 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
H9204_RS03740 (772904) 772904..773614 + 711 WP_000834030.1 hypothetical protein -
H9204_RS03745 (773621) 773621..773953 + 333 WP_000914690.1 DUF2645 family protein -
H9204_RS03750 (773999) 773999..775348 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
H9204_RS03755 (775345) 775345..776004 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
H9204_RS03760 (776156) 776156..776548 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H9204_RS03765 (776601) 776601..777083 + 483 WP_000183505.1 GyrI-like domain-containing protein -
H9204_RS03770 (777288) 777288..777584 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
H9204_RS03775 (777586) 777586..777981 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H9204_RS03780 (778114) 778114..779721 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
H9204_RS03785 (779859) 779859..782117 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T171435 WP_000415585.1 NZ_CP060908:777288-777584 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T171435 NZ_CP077921:2578357-2578566 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGATGGTCAAGTAACTGTATCGTATGAGACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT171435 WP_000650107.1 NZ_CP060908:777586-777981 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT171435 NZ_CP077921:2578052-2578345 [Staphylococcus aureus]
ATGACTGAACAAGATAATGCACATCATTCTGAACAAATAAAAACGAATCTTAAATCACGTTTAAATCGAATTGAAGGACA
AGTGAGAGCGATTAATCGCATGATTGAAGAAGATGTCTATTGTGATGATGTCCTTACGCAAATAAGAGCGACACGTTCGG
CGTTAAACAGTGTTGCGATAAAGTTATTAGAACAACATATGAAAAGTTGTATTATGAATAAAGTTAATCAAGGTGCTCAG
GAAGAGGCAATGGAAGAGTTATTAGTGACTTTTCAAAAATTGATTAAAGACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References