171352

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1886722..1887224 Replicon chromosome
Accession NZ_CP060892
Organism Escherichia coli strain EC22

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag H9207_RS08995 Protein ID WP_000767829.1
Coordinates 1886970..1887224 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag H9207_RS08990 Protein ID WP_001259255.1
Coordinates 1886722..1886973 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9207_RS08965 (1881899) 1881899..1882966 - 1068 WP_046464156.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
H9207_RS08970 (1882966) 1882966..1884036 - 1071 WP_000108945.1 histidinol-phosphate transaminase -
H9207_RS08975 (1884033) 1884033..1885337 - 1305 WP_001446927.1 histidinol dehydrogenase -
H9207_RS08980 (1885343) 1885343..1886242 - 900 WP_032329340.1 ATP phosphoribosyltransferase -
H9207_RS08985 (1886388) 1886388..1886438 - 51 WP_001364200.1 his operon leader peptide -
H9207_RS08990 (1886722) 1886722..1886973 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
H9207_RS08995 (1886970) 1886970..1887224 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
H9207_RS09000 (1887307) 1887307..1888131 + 825 WP_000754749.1 SDR family oxidoreductase -
H9207_RS09005 (1888177) 1888177..1889106 + 930 WP_000803351.1 LysR substrate-binding domain-containing protein -
H9207_RS09010 (1889321) 1889321..1889383 + 63 WP_010723108.1 membrane protein YoeI -
H9207_RS09015 (1889373) 1889373..1890731 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
H9207_RS09020 (1890910) 1890910..1891968 + 1059 WP_000492321.1 thiosulfate utilization transporter TsuA/YeeE -
H9207_RS09025 (1891982) 1891982..1892209 + 228 WP_000985273.1 thiosulfate utilization sulfurtransferase TsuB/YeeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T171352 WP_000767829.1 NZ_CP060892:1886970-1887224 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T171352 NZ_CP077897:350826-351014 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT171352 WP_001259255.1 NZ_CP060892:1886722-1886973 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT171352 NZ_CP077897:350537-350797 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LNR0

References