Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 41126..41390 Replicon plasmid pEC24-3
Accession NZ_CP060887
Organism Escherichia coli strain EC24

Toxin (Protein)


Gene name pndA Uniprot ID U9Z417
Locus tag H9208_RS24275 Protein ID WP_001387489.1
Coordinates 41238..41390 (+) Length 51 a.a.

Antitoxin (RNA)


Gene name pndB
Locus tag -
Coordinates 41126..41186 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9208_RS24260 (37228) 37228..38298 - 1071 WP_012783932.1 IncI1-type conjugal transfer protein TrbB -
H9208_RS24265 (38317) 38317..39525 - 1209 WP_001703845.1 IncI1-type conjugal transfer protein TrbA -
- (39705) 39705..39762 - 58 NuclAT_1 - -
- (39705) 39705..39762 - 58 NuclAT_1 - -
- (39705) 39705..39762 - 58 NuclAT_1 - -
- (39705) 39705..39762 - 58 NuclAT_1 - -
H9208_RS24270 (39832) 39832..40611 - 780 WP_275450201.1 protein FinQ -
- (41126) 41126..41186 - 61 NuclAT_0 - Antitoxin
- (41126) 41126..41186 - 61 NuclAT_0 - Antitoxin
- (41126) 41126..41186 - 61 NuclAT_0 - Antitoxin
- (41126) 41126..41186 - 61 NuclAT_0 - Antitoxin
H9208_RS24275 (41238) 41238..41390 + 153 WP_001387489.1 Hok/Gef family protein Toxin
H9208_RS24280 (41462) 41462..41713 - 252 WP_001291964.1 hypothetical protein -
H9208_RS24950 (42214) 42214..42309 + 96 WP_000609148.1 DinQ-like type I toxin DqlB -
H9208_RS24290 (42374) 42374..42550 - 177 WP_001054900.1 hypothetical protein -
H9208_RS24295 (42942) 42942..43151 + 210 WP_000062603.1 HEAT repeat domain-containing protein -
H9208_RS24300 (43223) 43223..43885 - 663 WP_012783935.1 plasmid IncI1-type surface exclusion protein ExcA -
H9208_RS24305 (43956) 43956..46124 - 2169 WP_015508354.1 DotA/TraY family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaCTX-M-55 - 1..86975 86975


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(7-46)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5761.10 Da        Isoelectric Point: 8.7948

>T171342 WP_001387489.1 NZ_CP060887:41238-41390 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR

Download         Length: 153 bp

>T171342 NZ_CP077893:c774817-774722 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 61 bp

>AT171342 NZ_CP060887:c41186-41126 [Escherichia coli]
GAGGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9Z417

Antitoxin

Download structure file

References