Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2495593..2496231 Replicon chromosome
Accession NZ_CP060880
Organism Escherichia coli strain EC26

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A6TXU8
Locus tag H9209_RS12160 Protein ID WP_001447010.1
Coordinates 2496055..2496231 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H9209_RS12155 Protein ID WP_001270286.1
Coordinates 2495593..2496009 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9209_RS12135 (2490745) 2490745..2491686 - 942 WP_001251304.1 ABC transporter permease -
H9209_RS12140 (2491687) 2491687..2492700 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
H9209_RS12145 (2492718) 2492718..2493863 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
H9209_RS12150 (2494108) 2494108..2495514 - 1407 WP_241424645.1 PLP-dependent aminotransferase family protein -
H9209_RS12155 (2495593) 2495593..2496009 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
H9209_RS12160 (2496055) 2496055..2496231 - 177 WP_001447010.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
H9209_RS12165 (2496453) 2496453..2496683 + 231 WP_000494244.1 YncJ family protein -
H9209_RS12170 (2496775) 2496775..2498736 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
H9209_RS12175 (2498809) 2498809..2499345 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
H9209_RS12180 (2499437) 2499437..2500612 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 2500652..2501800 1148


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6779.86 Da        Isoelectric Point: 11.2298

>T171305 WP_001447010.1 NZ_CP060880:c2496231-2496055 [Escherichia coli]
VKQSEFRRWLESQGVDVANSSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T171305 NZ_CP077880:c1648028-1647852 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT171305 WP_001270286.1 NZ_CP060880:c2496009-2495593 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT171305 NZ_CP077880:1647721-1647862 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAGTGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A6TXU8

Antitoxin

Source ID Structure

References