Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 714412..715105 Replicon chromosome
Accession NZ_CP060880
Organism Escherichia coli strain EC26

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag H9209_RS03460 Protein ID WP_000415584.1
Coordinates 714412..714708 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H9209_RS03465 Protein ID WP_000650107.1
Coordinates 714710..715105 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9209_RS03425 (709500) 709500..709814 - 315 WP_000958598.1 putative quinol monooxygenase -
H9209_RS03430 (709845) 709845..710426 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
H9209_RS03435 (710745) 710745..711077 + 333 WP_000917685.1 DUF2645 family protein -
H9209_RS03440 (711123) 711123..712472 - 1350 WP_241424668.1 quorum sensing histidine kinase QseC -
H9209_RS03445 (712469) 712469..713128 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
H9209_RS03450 (713280) 713280..713672 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H9209_RS03455 (713725) 713725..714207 + 483 WP_000183505.1 GyrI-like domain-containing protein -
H9209_RS03460 (714412) 714412..714708 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
H9209_RS03465 (714710) 714710..715105 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H9209_RS03470 (715238) 715238..716845 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
H9209_RS03475 (716983) 716983..719241 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T171290 WP_000415584.1 NZ_CP060880:714412-714708 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T171290 NZ_CP077877:c493837-493571 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT171290 WP_000650107.1 NZ_CP060880:714710-715105 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT171290 NZ_CP077877:c494088-493837 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References