Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | hok-sok/- |
| Location | 46886..47150 | Replicon | plasmid pEC27-3 |
| Accession | NZ_CP060875 | ||
| Organism | Escherichia coli strain EC27 | ||
Toxin (Protein)
| Gene name | pndA | Uniprot ID | U9Z417 |
| Locus tag | H9210_RS24190 | Protein ID | WP_001387489.1 |
| Coordinates | 46998..47150 (+) | Length | 51 a.a. |
Antitoxin (RNA)
| Gene name | pndB | ||
| Locus tag | - | ||
| Coordinates | 46886..46948 (-) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| H9210_RS24175 (42125) | 42125..44416 | - | 2292 | WP_241424639.1 | F-type conjugative transfer protein TrbC | - |
| H9210_RS24180 (44409) | 44409..45479 | - | 1071 | WP_000151583.1 | IncI1-type conjugal transfer protein TrbB | - |
| H9210_RS24185 (45498) | 45498..46706 | - | 1209 | WP_000121273.1 | IncI1-type conjugal transfer protein TrbA | - |
| - (46886) | 46886..46948 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (46886) | 46886..46948 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (46886) | 46886..46948 | - | 63 | NuclAT_0 | - | Antitoxin |
| - (46886) | 46886..46948 | - | 63 | NuclAT_0 | - | Antitoxin |
| H9210_RS24190 (46998) | 46998..47150 | + | 153 | WP_001387489.1 | Hok/Gef family protein | Toxin |
| H9210_RS24195 (47222) | 47222..47473 | - | 252 | WP_001291964.1 | hypothetical protein | - |
| H9210_RS25130 (47972) | 47972..48067 | + | 96 | WP_001303310.1 | DinQ-like type I toxin DqlB | - |
| H9210_RS24205 (48132) | 48132..48308 | - | 177 | WP_001054900.1 | hypothetical protein | - |
| H9210_RS24210 (48640) | 48640..48849 | + | 210 | WP_000062602.1 | HEAT repeat domain-containing protein | - |
| H9210_RS24215 (48921) | 48921..49583 | - | 663 | WP_000644792.1 | plasmid IncI1-type surface exclusion protein ExcA | - |
| H9210_RS24220 (49648) | 49648..51816 | - | 2169 | WP_241424633.1 | DotA/TraY family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaCTX-M-24 | - | 1..92062 | 92062 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 51 a.a. Molecular weight: 5761.10 Da Isoelectric Point: 8.7948
>T171284 WP_001387489.1 NZ_CP060875:46998-47150 [Escherichia coli]
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
MPQRTFLMMLIVVCVTILCFVWMVRDSLCGLRLQQGNTVLVATLAYEVKR
Download Length: 153 bp
>T171284 NZ_CP077872:2515928-2516194 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA
Antitoxin
Download Length: 63 bp
>AT171284 NZ_CP060875:c46948-46886 [Escherichia coli]
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
TCGAAGCATTACAGTAGAGCCCTTGGTTGATTGATAAAAAAATCTCCAGGGGCTTTCTGCTGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
