Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 775952..776645 Replicon chromosome
Accession NZ_CP060873
Organism Escherichia coli strain EC27

Toxin (Protein)


Gene name mqsR Uniprot ID U9ZN09
Locus tag H9210_RS03760 Protein ID WP_000415585.1
Coordinates 775952..776248 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H9210_RS03765 Protein ID WP_000650107.1
Coordinates 776250..776645 (+) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9210_RS03725 (771086) 771086..771565 + 480 WP_000065332.1 Hcp family type VI secretion system effector -
H9210_RS03730 (771568) 771568..772278 + 711 WP_000834030.1 hypothetical protein -
H9210_RS03735 (772285) 772285..772617 + 333 WP_000914690.1 DUF2645 family protein -
H9210_RS03740 (772663) 772663..774012 - 1350 WP_000673358.1 quorum sensing histidine kinase QseC -
H9210_RS03745 (774009) 774009..774668 - 660 WP_001221502.1 quorum sensing response regulator transcription factor QseB -
H9210_RS03750 (774820) 774820..775212 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H9210_RS03755 (775265) 775265..775747 + 483 WP_000183505.1 GyrI-like domain-containing protein -
H9210_RS03760 (775952) 775952..776248 + 297 WP_000415585.1 type II toxin-antitoxin system toxin MqsR Toxin
H9210_RS03765 (776250) 776250..776645 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H9210_RS03770 (776778) 776778..778385 + 1608 WP_001375094.1 ABC transporter substrate-binding protein -
H9210_RS03775 (778523) 778523..780781 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(2-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11261.99 Da        Isoelectric Point: 8.9070

>T171259 WP_000415585.1 NZ_CP060873:775952-776248 [Escherichia coli]
MEKRTPHTRLSQVKKLVNTGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T171259 NZ_CP077869:626459-626779 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT171259 WP_000650107.1 NZ_CP060873:776250-776645 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT171259 NZ_CP077869:626247-626456 [Staphylococcus aureus]
ATGAATAATGAACAAAAAGAAGTAATAGAACACTTGGTTTATCAACTTGAGTTAAGTGTCATGAATAATTTGGAAAGTTA
CGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZN09

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References