Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3952693..3953386 Replicon chromosome
Accession NZ_CP060867
Organism Escherichia coli strain EC29

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag H9211_RS19095 Protein ID WP_000415584.1
Coordinates 3953090..3953386 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H9211_RS19090 Protein ID WP_000650107.1
Coordinates 3952693..3953088 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9211_RS19080 (3948557) 3948557..3950815 - 2259 WP_032329482.1 DNA topoisomerase IV subunit A -
H9211_RS19085 (3950953) 3950953..3952560 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
H9211_RS19090 (3952693) 3952693..3953088 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H9211_RS19095 (3953090) 3953090..3953386 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
H9211_RS19100 (3953591) 3953591..3954073 - 483 WP_000183505.1 GyrI-like domain-containing protein -
H9211_RS19105 (3954126) 3954126..3954518 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H9211_RS19110 (3954670) 3954670..3955329 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
H9211_RS19115 (3955326) 3955326..3956675 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
H9211_RS19120 (3956721) 3956721..3957053 - 333 WP_000917685.1 DUF2645 family protein -
H9211_RS19125 (3957372) 3957372..3957953 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
H9211_RS19130 (3957984) 3957984..3958298 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T171242 WP_000415584.1 NZ_CP060867:c3953386-3953090 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T171242 NZ_CP077867:806432-806620 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT171242 WP_000650107.1 NZ_CP060867:c3953088-3952693 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT171242 NZ_CP077867:806143-806403 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References