Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4489512..4490266 Replicon chromosome
Accession NZ_CP060855
Organism Salmonella enterica strain 453

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IAQ58_RS21520 Protein ID WP_133323219.1
Coordinates 4489512..4489823 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IAQ58_RS21525 Protein ID WP_001259009.1
Coordinates 4489820..4490266 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAQ58_RS21490 (4485170) 4485170..4486072 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
IAQ58_RS21495 (4486069) 4486069..4486704 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
IAQ58_RS21500 (4486701) 4486701..4487630 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
IAQ58_RS21505 (4487677) 4487677..4487967 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
IAQ58_RS21510 (4487968) 4487968..4488279 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
IAQ58_RS21515 (4488497) 4488497..4489426 + 930 WP_001127694.1 alpha/beta hydrolase -
IAQ58_RS21520 (4489512) 4489512..4489823 + 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin Toxin
IAQ58_RS21525 (4489820) 4489820..4490266 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
IAQ58_RS21530 (4490281) 4490281..4491222 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
IAQ58_RS21535 (4491267) 4491267..4491704 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
IAQ58_RS21540 (4491701) 4491701..4492573 - 873 WP_000921423.1 virulence factor BrkB family protein -
IAQ58_RS21545 (4492567) 4492567..4493166 - 600 WP_000965698.1 glucose-1-phosphatase -
IAQ58_RS21550 (4493357) 4493357..4494160 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
IAQ58_RS21555 (4494194) 4494194..4495090 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12490.44 Da        Isoelectric Point: 9.1995

>T171213 WP_133323219.1 NZ_CP060855:4489512-4489823 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T171213 NZ_CP077861:c228855-228679 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT171213 WP_001259009.1 NZ_CP060855:4489820-4490266 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT171213 NZ_CP077861:228556-228611 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References