Detailed information of TA system TA171212

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4487677..4488279
• Replicon: chromosome
• Accession: NZ_CP060855
• Organism: Salmonella enterica strain 453

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: IAQ58_RS21510
• Protein ID: WP_001159630.1
• Coordinates: 4487968..4488279 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IAQ58_RS21505
• Protein ID: WP_000362050.1
• Coordinates: 4487677..4487967 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAQ58_RS21490 (4485170)	4485170..4486072	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
IAQ58_RS21495 (4486069)	4486069..4486704	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
IAQ58_RS21500 (4486701)	4486701..4487630	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IAQ58_RS21505 (4487677)	4487677..4487967	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
IAQ58_RS21510 (4487968)	4487968..4488279	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
IAQ58_RS21515 (4488497)	4488497..4489426	+	930	WP_001127694.1	alpha/beta hydrolase	-
IAQ58_RS21520 (4489512)	4489512..4489823	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
IAQ58_RS21525 (4489820)	4489820..4490266	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
IAQ58_RS21530 (4490281)	4490281..4491222	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IAQ58_RS21535 (4491267)	4491267..4491704	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
IAQ58_RS21540 (4491701)	4491701..4492573	-	873	WP_000921423.1	virulence factor BrkB family protein	-
IAQ58_RS21545 (4492567)	4492567..4493166	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T171212 WP_001159630.1 NZ_CP060855:c4488279-4487968 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T171212 NZ_CP077860:c2527128-2526940 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT171212 WP_000362050.1 NZ_CP060855:c4487967-4487677 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT171212 NZ_CP077860:c2527417-2527157 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATCGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64