Detailed information of TA system TA171193

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4520414..4521016
• Replicon: chromosome
• Accession: NZ_CP060852
• Organism: Salmonella enterica strain 467

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: IAR30_RS21645
• Protein ID: WP_001159630.1
• Coordinates: 4520705..4521016 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IAR30_RS21640
• Protein ID: WP_000362050.1
• Coordinates: 4520414..4520704 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR30_RS21625 (4517907)	4517907..4518809	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
IAR30_RS21630 (4518806)	4518806..4519441	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
IAR30_RS21635 (4519438)	4519438..4520367	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IAR30_RS21640 (4520414)	4520414..4520704	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
IAR30_RS21645 (4520705)	4520705..4521016	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
IAR30_RS21650 (4521234)	4521234..4522163	+	930	WP_001127694.1	alpha/beta hydrolase	-
IAR30_RS21655 (4522249)	4522249..4522560	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
IAR30_RS21660 (4522557)	4522557..4523003	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
IAR30_RS21665 (4523018)	4523018..4523959	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IAR30_RS21670 (4524004)	4524004..4524441	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
IAR30_RS21675 (4524438)	4524438..4525310	-	873	WP_000921423.1	virulence factor BrkB family protein	-
IAR30_RS21680 (4525304)	4525304..4525903	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T171193 WP_001159630.1 NZ_CP060852:c4521016-4520705 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T171193 NZ_CP077859:2171332-2171598 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT171193 WP_000362050.1 NZ_CP060852:c4520704-4520414 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT171193 NZ_CP077859:2171075-2171332 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64