Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 1394545..1395147 Replicon chromosome
Accession NZ_CP060849
Organism Salmonella enterica strain 724

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag IAR31_RS06860 Protein ID WP_001159630.1
Coordinates 1394545..1394856 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IAR31_RS06865 Protein ID WP_000362050.1
Coordinates 1394857..1395147 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR31_RS06825 (1389658) 1389658..1390257 + 600 WP_000965698.1 glucose-1-phosphatase -
IAR31_RS06830 (1390251) 1390251..1391123 + 873 WP_000921423.1 virulence factor BrkB family protein -
IAR31_RS06835 (1391120) 1391120..1391557 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
IAR31_RS06840 (1391602) 1391602..1392543 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
IAR31_RS06845 (1392558) 1392558..1393004 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
IAR31_RS06850 (1393001) 1393001..1393312 - 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin -
IAR31_RS06855 (1393398) 1393398..1394327 - 930 WP_001127694.1 alpha/beta hydrolase -
IAR31_RS06860 (1394545) 1394545..1394856 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
IAR31_RS06865 (1394857) 1394857..1395147 + 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
IAR31_RS06870 (1395194) 1395194..1396123 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
IAR31_RS06875 (1396120) 1396120..1396755 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
IAR31_RS06880 (1396752) 1396752..1397654 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T171162 WP_001159630.1 NZ_CP060849:1394545-1394856 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T171162 NZ_CP077856:2207448-2207555 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT171162 WP_000362050.1 NZ_CP060849:1394857-1395147 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT171162 NZ_CP077856:c2207632-2207572 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References