Detailed information of TA system TA171161

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 1392558..1393312
• Replicon: chromosome
• Accession: NZ_CP060849
• Organism: Salmonella enterica strain 724

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: IAR31_RS06850
• Protein ID: WP_133323219.1
• Coordinates: 1393001..1393312 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IAR31_RS06845
• Protein ID: WP_001259009.1
• Coordinates: 1392558..1393004 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR31_RS06815 (1387734)	1387734..1388630	+	897	WP_001520529.1	sugar kinase	-
IAR31_RS06820 (1388664)	1388664..1389467	+	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
IAR31_RS06825 (1389658)	1389658..1390257	+	600	WP_000965698.1	glucose-1-phosphatase	-
IAR31_RS06830 (1390251)	1390251..1391123	+	873	WP_000921423.1	virulence factor BrkB family protein	-
IAR31_RS06835 (1391120)	1391120..1391557	+	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
IAR31_RS06840 (1391602)	1391602..1392543	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IAR31_RS06845 (1392558)	1392558..1393004	-	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
IAR31_RS06850 (1393001)	1393001..1393312	-	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	Toxin
IAR31_RS06855 (1393398)	1393398..1394327	-	930	WP_001127694.1	alpha/beta hydrolase	-
IAR31_RS06860 (1394545)	1394545..1394856	+	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
IAR31_RS06865 (1394857)	1394857..1395147	+	291	WP_000362050.1	DNA-binding transcriptional regulator	-
IAR31_RS06870 (1395194)	1395194..1396123	-	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IAR31_RS06875 (1396120)	1396120..1396755	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
IAR31_RS06880 (1396752)	1396752..1397654	-	903	WP_000331364.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12490.44 Da
• Isoelectric Point: 9.1995

>T171161 WP_133323219.1 NZ_CP060849:c1393312-1393001 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T171161 NZ_CP077856:2176164-2176430 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAGGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCTTTTGAAAAATTAGAGCCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTAATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16720.06 Da
• Isoelectric Point: 6.6451

>AT171161 WP_001259009.1 NZ_CP060849:c1393004-1392558 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT171161 NZ_CP077856:2175907-2176164 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAATAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTTTAA