Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4490408..4491162 Replicon chromosome
Accession NZ_CP060846
Organism Salmonella enterica strain 733

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IAR32_RS21510 Protein ID WP_133323219.1
Coordinates 4490408..4490719 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IAR32_RS21515 Protein ID WP_001259009.1
Coordinates 4490716..4491162 (+) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR32_RS21480 (4486066) 4486066..4486968 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
IAR32_RS21485 (4486965) 4486965..4487600 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
IAR32_RS21490 (4487597) 4487597..4488526 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
IAR32_RS21495 (4488573) 4488573..4488863 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
IAR32_RS21500 (4488864) 4488864..4489175 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
IAR32_RS21505 (4489393) 4489393..4490322 + 930 WP_001127694.1 alpha/beta hydrolase -
IAR32_RS21510 (4490408) 4490408..4490719 + 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin Toxin
IAR32_RS21515 (4490716) 4490716..4491162 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
IAR32_RS21520 (4491177) 4491177..4492118 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
IAR32_RS21525 (4492163) 4492163..4492600 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
IAR32_RS21530 (4492597) 4492597..4493469 - 873 WP_000921423.1 virulence factor BrkB family protein -
IAR32_RS21535 (4493463) 4493463..4494062 - 600 WP_000965698.1 glucose-1-phosphatase -
IAR32_RS21540 (4494253) 4494253..4495056 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
IAR32_RS21545 (4495090) 4495090..4495986 - 897 WP_001520529.1 sugar kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12490.44 Da        Isoelectric Point: 9.1995

>T171156 WP_133323219.1 NZ_CP060846:4490408-4490719 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T171156 NZ_CP077855:2731979-2732086 [Staphylococcus aureus]
ATGTTCAATTTATTAATTAACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT171156 WP_001259009.1 NZ_CP060846:4490716-4491162 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT171156 NZ_CP077855:c2732163-2732103 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References