Detailed information of TA system TA171124

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 1100400..1101002
• Replicon: chromosome
• Accession: NZ_CP060844
• Organism: Salmonella enterica strain 770

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: IAR33_RS05295
• Protein ID: WP_001159630.1
• Coordinates: 1100400..1100711 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IAR33_RS05300
• Protein ID: WP_000362050.1
• Coordinates: 1100712..1101002 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR33_RS05260 (1095513)	1095513..1096112	+	600	WP_000965698.1	glucose-1-phosphatase	-
IAR33_RS05265 (1096106)	1096106..1096978	+	873	WP_000921423.1	virulence factor BrkB family protein	-
IAR33_RS05270 (1096975)	1096975..1097412	+	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
IAR33_RS05275 (1097457)	1097457..1098398	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IAR33_RS05280 (1098413)	1098413..1098859	-	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
IAR33_RS05285 (1098856)	1098856..1099167	-	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
IAR33_RS05290 (1099253)	1099253..1100182	-	930	WP_001127694.1	alpha/beta hydrolase	-
IAR33_RS05295 (1100400)	1100400..1100711	+	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
IAR33_RS05300 (1100712)	1100712..1101002	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
IAR33_RS05305 (1101049)	1101049..1101978	-	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IAR33_RS05310 (1101975)	1101975..1102610	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
IAR33_RS05315 (1102607)	1102607..1103509	-	903	WP_000331364.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T171124 WP_001159630.1 NZ_CP060844:1100400-1100711 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T171124 NZ_CP077852:c2754875-2754723 [Staphylococcus aureus]
ATGTCTAAAGACAAAGATCCAAAATTAAATTATCATGAAGAAGAAAACAGTATGGTAACGGATTTTGAAGATTTAAAAGA
ATTAGGTAAAGAAATGGAACAAATCTCTGATCAAAATGATCAAGAAAAAAATTCTGAAGAAGACAGTCAGTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT171124 WP_000362050.1 NZ_CP060844:1100712-1101002 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT171124 NZ_CP077852:c2755499-2754900 [Staphylococcus aureus]
ATGGCAATGAACTTTAAAGTCTTTGACAATAGTCAACTTGTAGCAGAATATGCTGCTGATATTATTAGAAAGCAATTTAA
CAATAATCCTACTACAATTGCAGGTTTTCATTTAGATACAGATCAAGCGCCAGTTCTAGATGAATTAAAGAAAAATGTTG
AAAAACATGCTGTTGATTTTAGCCAAATAAATATTTTAGATTATGACGATAAAAAATCATATTTCGAAGCGTTAGGTGTA
CCAGCAGGTCAAGTTTATCCAATTGCTTATGAAAAAGATGCAATCGAATTAATCGCTGATAAGATTAAAACTAAAGAAAA
TAAAGGGAAATTAACATTACAAGTTGTTTCTATCGATGAGCAAGGTAAGTTAAATGTTAGTATTCGTCAAGGACTAATGG
AAGCAAGAGAAATTTTCTTAGTAGTGACAGGTGCTAATAAACGAGATGTAGTTGAAAAATTATATCAAGAAAATGGTAAA
ACAAGCTTCGAACCAGCCGATTTAAAAGCACATAGAATGGTAAATGTTATTCTTGATAAAGAAGCGGCTGCAGGTTTACC
TGAAGATGTTAAAGCTTACTTTACGTCACGCTTTGCTTAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64