Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1098413..1099167 Replicon chromosome
Accession NZ_CP060844
Organism Salmonella enterica strain 770

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag IAR33_RS05285 Protein ID WP_133323219.1
Coordinates 1098856..1099167 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IAR33_RS05280 Protein ID WP_001259009.1
Coordinates 1098413..1098859 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR33_RS05250 (1093589) 1093589..1094485 + 897 WP_001520529.1 sugar kinase -
IAR33_RS05255 (1094519) 1094519..1095322 + 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
IAR33_RS05260 (1095513) 1095513..1096112 + 600 WP_000965698.1 glucose-1-phosphatase -
IAR33_RS05265 (1096106) 1096106..1096978 + 873 WP_000921423.1 virulence factor BrkB family protein -
IAR33_RS05270 (1096975) 1096975..1097412 + 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
IAR33_RS05275 (1097457) 1097457..1098398 + 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
IAR33_RS05280 (1098413) 1098413..1098859 - 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
IAR33_RS05285 (1098856) 1098856..1099167 - 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin Toxin
IAR33_RS05290 (1099253) 1099253..1100182 - 930 WP_001127694.1 alpha/beta hydrolase -
IAR33_RS05295 (1100400) 1100400..1100711 + 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system -
IAR33_RS05300 (1100712) 1100712..1101002 + 291 WP_000362050.1 DNA-binding transcriptional regulator -
IAR33_RS05305 (1101049) 1101049..1101978 - 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
IAR33_RS05310 (1101975) 1101975..1102610 - 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
IAR33_RS05315 (1102607) 1102607..1103509 - 903 WP_000331364.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, mRNA interferase HigB

(21-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(93-146)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12490.44 Da        Isoelectric Point: 9.1995

>T171123 WP_133323219.1 NZ_CP060844:c1099167-1098856 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T171123 NZ_CP077852:2703214-2703309 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16720.06 Da        Isoelectric Point: 6.6451

>AT171123 WP_001259009.1 NZ_CP060844:c1098859-1098413 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT171123 NZ_CP077852:c2703394-2703337 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References