Detailed information of TA system TA171119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4458689..4459443
• Replicon: chromosome
• Accession: NZ_CP060840
• Organism: Salmonella enterica strain 805

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: IAR34_RS21275
• Protein ID: WP_133323219.1
• Coordinates: 4458689..4459000 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IAR34_RS21280
• Protein ID: WP_001259009.1
• Coordinates: 4458997..4459443 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR34_RS21245 (4454347)	4454347..4455249	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
IAR34_RS21250 (4455246)	4455246..4455881	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
IAR34_RS21255 (4455878)	4455878..4456807	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IAR34_RS21260 (4456854)	4456854..4457144	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
IAR34_RS21265 (4457145)	4457145..4457456	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
IAR34_RS21270 (4457674)	4457674..4458603	+	930	WP_001127694.1	alpha/beta hydrolase	-
IAR34_RS21275 (4458689)	4458689..4459000	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	Toxin
IAR34_RS21280 (4458997)	4458997..4459443	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
IAR34_RS21285 (4459458)	4459458..4460399	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IAR34_RS21290 (4460444)	4460444..4460881	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
IAR34_RS21295 (4460878)	4460878..4461750	-	873	WP_000921423.1	virulence factor BrkB family protein	-
IAR34_RS21300 (4461744)	4461744..4462343	-	600	WP_000965698.1	glucose-1-phosphatase	-
IAR34_RS21305 (4462534)	4462534..4463337	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
IAR34_RS21310 (4463371)	4463371..4464267	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12490.44 Da
• Isoelectric Point: 9.1995

>T171119 WP_133323219.1 NZ_CP060840:4458689-4459000 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T171119 NZ_CP077852:c526409-526143 [Staphylococcus aureus]
ATGGCTAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGAAGATTATAAGTATTTTCAGCAGAACAATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGTGCATTGGAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATACAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16720.06 Da
• Isoelectric Point: 6.6451

>AT171119 WP_001259009.1 NZ_CP060840:4458997-4459443 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT171119 NZ_CP077852:c526660-526409 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAACCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA