Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HTH(antitoxin)
Location 4456854..4457456 Replicon chromosome
Accession NZ_CP060840
Organism Salmonella enterica strain 805

Toxin (Protein)


Gene name higB Uniprot ID C0Q3J8
Locus tag IAR34_RS21265 Protein ID WP_001159630.1
Coordinates 4457145..4457456 (-) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag IAR34_RS21260 Protein ID WP_000362050.1
Coordinates 4456854..4457144 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAR34_RS21245 (4454347) 4454347..4455249 + 903 WP_000331364.1 formate dehydrogenase subunit beta -
IAR34_RS21250 (4455246) 4455246..4455881 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
IAR34_RS21255 (4455878) 4455878..4456807 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
IAR34_RS21260 (4456854) 4456854..4457144 - 291 WP_000362050.1 DNA-binding transcriptional regulator Antitoxin
IAR34_RS21265 (4457145) 4457145..4457456 - 312 WP_001159630.1 cytotoxic translational repressor of toxin-antitoxin stability system Toxin
IAR34_RS21270 (4457674) 4457674..4458603 + 930 WP_001127694.1 alpha/beta hydrolase -
IAR34_RS21275 (4458689) 4458689..4459000 + 312 WP_133323219.1 type II toxin-antitoxin system HigB family toxin -
IAR34_RS21280 (4458997) 4458997..4459443 + 447 WP_001259009.1 type II toxin-antitoxin system HigA family antitoxin -
IAR34_RS21285 (4459458) 4459458..4460399 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
IAR34_RS21290 (4460444) 4460444..4460881 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
IAR34_RS21295 (4460878) 4460878..4461750 - 873 WP_000921423.1 virulence factor BrkB family protein -
IAR34_RS21300 (4461744) 4461744..4462343 - 600 WP_000965698.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(36-85)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 12326.27 Da        Isoelectric Point: 9.4460

>T171118 WP_001159630.1 NZ_CP060840:c4457456-4457145 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Download         Length: 312 bp

>T171118 NZ_CP077852:c266728-266624 [Staphylococcus aureus]
TTGTTACTCCTAGAAAGGACTAGCATGTCTGATTTTGAAATGCTGATGGTTGTATTAACAATCATTGGTTTAGTATTGAT
TAGTACTCAAGACCATAAAAAATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10971.59 Da        Isoelectric Point: 10.6525

>AT171118 WP_000362050.1 NZ_CP060840:c4457144-4456854 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Download         Length: 291 bp

>AT171118 NZ_CP077852:266531-266569 [Staphylococcus aureus]
AACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGAC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NS64

Antitoxin

Source ID Structure

References