Detailed information of TA system TA171099

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4500991..4501593
• Replicon: chromosome
• Accession: NZ_CP060837
• Organism: Salmonella enterica strain 852

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: IAR35_RS21585
• Protein ID: WP_001159630.1
• Coordinates: 4501282..4501593 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IAR35_RS21580
• Protein ID: WP_000362050.1
• Coordinates: 4500991..4501281 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR35_RS21565 (4498484)	4498484..4499386	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
IAR35_RS21570 (4499383)	4499383..4500018	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
IAR35_RS21575 (4500015)	4500015..4500944	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IAR35_RS21580 (4500991)	4500991..4501281	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
IAR35_RS21585 (4501282)	4501282..4501593	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
IAR35_RS21590 (4501811)	4501811..4502740	+	930	WP_001127694.1	alpha/beta hydrolase	-
IAR35_RS21595 (4502826)	4502826..4503137	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
IAR35_RS21600 (4503134)	4503134..4503580	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
IAR35_RS21605 (4503595)	4503595..4504536	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IAR35_RS21610 (4504581)	4504581..4505018	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
IAR35_RS21615 (4505015)	4505015..4505887	-	873	WP_000921423.1	virulence factor BrkB family protein	-
IAR35_RS21620 (4505881)	4505881..4506480	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T171099 WP_001159630.1 NZ_CP060837:c4501593-4501282 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T171099 NZ_CP077842:2607-2963 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAATGAATGGCTTGAACAGCAAGATGAAGCAACACAAGAGAAAGTCTTAGC
TGCATTGGTTGTTCTACAACAGCAAGGGCCTAGTTTAGGTCGTCCTTTAGTAGATACCGTCTACGATTCTAAATTTACCA
ATATGAAGGAACTACGTGTTCAGCATCGTGGTAAACCGTTAAGGGCATTTTTTGCATTCGATCCCCTAAGACAAGCGATT
GTGCTGTGTATTGGTGATAAGAGTAATAAAAAGCGTTTTTATACAGAGATGCTAGCAATTGCAGATGAGCAATACGCACT
TCATCTCTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT171099 WP_000362050.1 NZ_CP060837:c4501281-4500991 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT171099 NZ_CP077842:2956-3258 [Acinetobacter baumannii]
ATGGCTAAGAGCTTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTTTTAGAAAGTCAGCTTCACCTTATCCGAGAAGAGTTAGAAATTTCCCAGAAAGAACTAGCTGCAACCCTTGGAATTA
AACAGCCGTCATTATCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGTGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGGTTCAATGTCTAA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64