Detailed information of TA system TA171081

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4490708..4491462
• Replicon: chromosome
• Accession: NZ_CP060834
• Organism: Salmonella enterica strain 1505

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: IAR36_RS21520
• Protein ID: WP_133323219.1
• Coordinates: 4490708..4491019 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IAR36_RS21525
• Protein ID: WP_001259009.1
• Coordinates: 4491016..4491462 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR36_RS21490 (4486366)	4486366..4487268	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
IAR36_RS21495 (4487265)	4487265..4487900	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
IAR36_RS21500 (4487897)	4487897..4488826	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IAR36_RS21505 (4488873)	4488873..4489163	-	291	WP_000362050.1	DNA-binding transcriptional regulator	-
IAR36_RS21510 (4489164)	4489164..4489475	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
IAR36_RS21515 (4489693)	4489693..4490622	+	930	WP_001127694.1	alpha/beta hydrolase	-
IAR36_RS21520 (4490708)	4490708..4491019	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	Toxin
IAR36_RS21525 (4491016)	4491016..4491462	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
IAR36_RS21530 (4491477)	4491477..4492418	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IAR36_RS21535 (4492463)	4492463..4492900	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
IAR36_RS21540 (4492897)	4492897..4493769	-	873	WP_000921423.1	virulence factor BrkB family protein	-
IAR36_RS21545 (4493763)	4493763..4494362	-	600	WP_000965698.1	glucose-1-phosphatase	-
IAR36_RS21550 (4494553)	4494553..4495356	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
IAR36_RS21555 (4495390)	4495390..4496286	-	897	WP_001520529.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12490.44 Da
• Isoelectric Point: 9.1995

>T171081 WP_133323219.1 NZ_CP060834:4490708-4491019 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSDNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T171081 NZ_CP077828:2695806-2696060 [Acinetobacter baumannii]
TTGCAAGCTTTCTTTGAAGAAGGCTCAACTGCTGGTATCCAAGCTGCTCACTCTAAGAAATTACGTTTACTTTTAGCTTC
ATTGAATGCTGCCACCTCAGTTTATGACTTGAGGACACCACCAAATTGGCGCTTACATGAATTAAAAGGCAATCTTGAAG
GTCATTGGTCTTTAACTGTAAACGGAAATTGGCGTGTAACGTTTAAATTTGAAGATGGCGATGCATACATCGTGGATTAT
CAAGATTATCACTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16720.06 Da
• Isoelectric Point: 6.6451

>AT171081 WP_001259009.1 NZ_CP060834:4491016-4491462 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT171081 NZ_CP077828:2696090-2696374 [Acinetobacter baumannii]
ATGAAAGTTATGTTTAATGCACCACACCCTGGCGAAATTCTTCAAGAGTATCTAGAGGGCATTTCAGTTACTAGCGCAGC
ACGAGCATTGGGCGTTACTCGTGCAAACTTATCTCGCATCCTCAATGGCCATACTGGTATATCAGCTGATATGGCGCTTC
GTCTTTCTGAAGCCCTTAGCACCTCACCAGAATTCTGGTTAAACTTGCAAGTACAGTATGATCTTTGGATTGCCAGCCAA
AATAAGCGGCCAACGATTCAGCATTTAGCGCCAGCAATGGCATAA