Detailed information of TA system TA171080

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 4488873..4489475
• Replicon: chromosome
• Accession: NZ_CP060834
• Organism: Salmonella enterica strain 1505

Toxin (Protein)

• Gene name: higB
• Uniprot ID: C0Q3J8
• Locus tag: IAR36_RS21510
• Protein ID: WP_001159630.1
• Coordinates: 4489164..4489475 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IAR36_RS21505
• Protein ID: WP_000362050.1
• Coordinates: 4488873..4489163 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAR36_RS21490 (4486366)	4486366..4487268	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
IAR36_RS21495 (4487265)	4487265..4487900	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
IAR36_RS21500 (4487897)	4487897..4488826	+	930	WP_000027730.1	formate dehydrogenase accessory protein FdhE	-
IAR36_RS21505 (4488873)	4488873..4489163	-	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
IAR36_RS21510 (4489164)	4489164..4489475	-	312	WP_001159630.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
IAR36_RS21515 (4489693)	4489693..4490622	+	930	WP_001127694.1	alpha/beta hydrolase	-
IAR36_RS21520 (4490708)	4490708..4491019	+	312	WP_133323219.1	type II toxin-antitoxin system HigB family toxin	-
IAR36_RS21525 (4491016)	4491016..4491462	+	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
IAR36_RS21530 (4491477)	4491477..4492418	-	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
IAR36_RS21535 (4492463)	4492463..4492900	-	438	WP_000560969.1	D-aminoacyl-tRNA deacylase	-
IAR36_RS21540 (4492897)	4492897..4493769	-	873	WP_000921423.1	virulence factor BrkB family protein	-
IAR36_RS21545 (4493763)	4493763..4494362	-	600	WP_000965698.1	glucose-1-phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12326.27 Da
• Isoelectric Point: 9.4460

>T171080 WP_001159630.1 NZ_CP060834:c4489475-4489164 [Salmonella enterica]
MQFIETELFTEDVKKLLDDDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T171080 NZ_CP060834:c4489475-4489164 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGATGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT171080 WP_000362050.1 NZ_CP060834:c4489163-4488873 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT171080 NZ_CP060834:c4489163-4488873 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGGTATTGA

Structures

Toxin

• AlphaFold DB: A0A0R9NS64