Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/RelE-HTH |
| Location | 123126..123711 | Replicon | plasmid pXM9F202-2-186k |
| Accession | NZ_CP060812 | ||
| Organism | Acinetobacter variabilis strain XM9F202-2 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | N9TNV9 |
| Locus tag | IAQ69_RS15805 | Protein ID | WP_004755868.1 |
| Coordinates | 123391..123711 (-) | Length | 107 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | IAQ69_RS15800 | Protein ID | WP_004896911.1 |
| Coordinates | 123126..123398 (-) | Length | 91 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IAQ69_RS15770 | 118563..119582 | - | 1020 | WP_159139009.1 | IS21 family transposase | - |
| IAQ69_RS15775 | 119696..119827 | - | 132 | Protein_117 | DUF3363 domain-containing protein | - |
| IAQ69_RS15780 | 119826..120855 | - | 1030 | Protein_118 | IS3 family transposase | - |
| IAQ69_RS15785 | 121038..121604 | - | 567 | WP_006581699.1 | recombinase family protein | - |
| IAQ69_RS15790 | 121923..122075 | + | 153 | Protein_120 | monooxygenase | - |
| IAQ69_RS15795 | 122312..123016 | - | 705 | WP_180058100.1 | IS6 family transposase | - |
| IAQ69_RS15800 | 123126..123398 | - | 273 | WP_004896911.1 | helix-turn-helix domain-containing protein | Antitoxin |
| IAQ69_RS15805 | 123391..123711 | - | 321 | WP_004755868.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| IAQ69_RS15810 | 123858..124589 | - | 732 | WP_166138371.1 | EcsC family protein | - |
| IAQ69_RS15815 | 124771..125067 | + | 297 | WP_005175534.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| IAQ69_RS15820 | 125069..125359 | + | 291 | WP_060875721.1 | putative addiction module antidote protein | - |
| IAQ69_RS15825 | 125446..125790 | - | 345 | WP_004282115.1 | hypothetical protein | - |
| IAQ69_RS15830 | 125802..126068 | - | 267 | WP_004282113.1 | DUF4258 domain-containing protein | - |
| IAQ69_RS15835 | 126235..126717 | + | 483 | WP_166138373.1 | hypothetical protein | - |
| IAQ69_RS15840 | 126710..127021 | + | 312 | WP_004282111.1 | hypothetical protein | - |
| IAQ69_RS15845 | 127162..127551 | - | 390 | WP_121594982.1 | tautomerase family protein | - |
| IAQ69_RS15850 | 127815..128186 | + | 372 | WP_004726814.1 | hypothetical protein | - |
| IAQ69_RS15855 | 128288..128533 | + | 246 | WP_166138376.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(M) / sul2 / aph(3')-Ia / aph(3'')-Ib / aph(6)-Id / aac(3)-IId / msr(E) / mph(E) / floR | - | 1..186242 | 186242 | |
| - | inside | IScluster/Tn | aph(3')-Ia / aph(3'')-Ib / aph(6)-Id / aac(3)-IId / msr(E) / mph(E) / floR | - | 87389..123016 | 35627 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 107 a.a. Molecular weight: 12210.98 Da Isoelectric Point: 7.9835
>T171040 WP_004755868.1 NZ_CP060812:c123711-123391 [Acinetobacter variabilis]
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSTKDNLTDKETSILRQLVKEQFHG
MLFIETSIFTKQIKELVSDEEYRQLQQDLLVQPDKGDLIKNGGGIRKVRCAQGNKGKSGGIRVIYYWVTEDDQIFFLVAY
PKSTKDNLTDKETSILRQLVKEQFHG
Download Length: 321 bp
>T171040 NZ_CP077818:2461281-2461814 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTTTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTTGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTTTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTTGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA
Antitoxin
Download Length: 91 a.a. Molecular weight: 10126.59 Da Isoelectric Point: 7.2045
>AT171040 WP_004896911.1 NZ_CP060812:c123398-123126 [Acinetobacter variabilis]
MDNNLFDDLVASIKEAGAIKRNEMKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI
MDNNLFDDLVASIKEAGAIKRNEMKASRVTELELPDIKEVREKTGLTQAEFAARLHISARTLQNWEQGRRYPTGPAATLI
RILDAHPTLI
Download Length: 273 bp
>AT171040 NZ_CP077818:2461004-2461270 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCCGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCCGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|