Detailed information of TA system TA171036

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/COG4683-HTH_37
• Location: 1711103..1711754
• Replicon: chromosome
• Accession: NZ_CP060811
• Organism: Acinetobacter variabilis strain XM9F202-2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: IAQ69_RS08050
• Protein ID: WP_179992580.1
• Coordinates: 1711407..1711754 (-)
• Length: 116 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: IAQ69_RS08045
• Protein ID: WP_179992579.1
• Coordinates: 1711103..1711405 (-)
• Length: 101 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IAQ69_RS08030	1706784..1707227	-	444	WP_200228552.1	transcriptional regulator	-
IAQ69_RS08035	1707963..1708964	+	1002	WP_179992577.1	OmpA family protein	-
IAQ69_RS08040	1709048..1710967	+	1920	WP_200228554.1	AAA family ATPase	-
IAQ69_RS08045	1711103..1711405	-	303	WP_179992579.1	XRE family transcriptional regulator	Antitoxin
IAQ69_RS08050	1711407..1711754	-	348	WP_179992580.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IAQ69_RS08055	1711849..1713153	-	1305	WP_159124594.1	IS4 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1699490..1713153	13663

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (33-81)

Sequences

Toxin

Protein

• Length: 116 a.a.
• Molecular weight: 13162.11 Da
• Isoelectric Point: 7.1638

>T171036 WP_179992580.1 NZ_CP060811:c1711754-1711407 [Acinetobacter variabilis]
MWTVLTTDVFNEWLEQQDESTQEKVLAALVVLQSQGPSLGRPLVDTIYNSKYTNMKELRVQHRGKPIRAFFAFDPLRQAI
VLCIGDKSGNKRFYTEMLAIADEQYSLHLKSLGVN

Nucleotide

• Length: 348 bp

>T171036 NZ_CP077818:c935154-934744 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 101 a.a.
• Molecular weight: 11324.16 Da
• Isoelectric Point: 6.2377

>AT171036 WP_179992579.1 NZ_CP060811:c1711405-1711103 [Acinetobacter variabilis]
MAKTLQELLAKRSPESQARIQEMAEELLLEQHLHMIREELEISQKELAETLGIKQPSLSAIENRGNDLKISTMKKYVEAM
GGKLRIDVELPTGKHIGFNV

Nucleotide

• Length: 303 bp

>AT171036 NZ_CP077818:c935401-935135 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA