Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 20950..21501 Replicon plasmid p2757-40
Accession NZ_CP060809
Organism Klebsiella variicola strain KP2757

Toxin (Protein)


Gene name yafQ Uniprot ID A0A7H0EV41
Locus tag IAP99_RS27225 Protein ID WP_073535404.1
Coordinates 20950..21234 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A7H0EV42
Locus tag IAP99_RS27230 Protein ID WP_073535405.1
Coordinates 21241..21501 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAP99_RS27180 16662..17006 + 345 WP_187726415.1 hypothetical protein -
IAP99_RS27185 17074..17499 + 426 WP_100027601.1 H-NS histone family protein -
IAP99_RS27190 17511..17834 + 324 WP_073535429.1 hypothetical protein -
IAP99_RS27195 18104..18889 + 786 WP_187726416.1 SprT-like domain-containing protein -
IAP99_RS27200 18891..19457 + 567 WP_187726417.1 hypothetical protein -
IAP99_RS27205 19454..20089 + 636 WP_073535401.1 hypothetical protein -
IAP99_RS27210 20116..20469 + 354 WP_187726418.1 hypothetical protein -
IAP99_RS27215 20509..20661 + 153 WP_187661356.1 hypothetical protein -
IAP99_RS27220 20672..20875 + 204 WP_073535403.1 hypothetical protein -
IAP99_RS27225 20950..21234 - 285 WP_073535404.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
IAP99_RS27230 21241..21501 - 261 WP_073535405.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IAP99_RS27235 21674..21889 + 216 WP_073535406.1 hypothetical protein -
IAP99_RS27240 21889..22389 + 501 WP_073535407.1 thermonuclease family protein -
IAP99_RS27245 22395..22703 + 309 WP_073535408.1 hypothetical protein -
IAP99_RS27250 22716..22952 + 237 WP_187726405.1 hypothetical protein -
IAP99_RS27255 23054..23341 + 288 WP_073535410.1 hypothetical protein -
IAP99_RS27260 23385..23690 + 306 WP_073535411.1 hypothetical protein -
IAP99_RS27265 23701..24105 + 405 WP_187726406.1 hypothetical protein -
IAP99_RS27270 24149..24607 + 459 WP_187726407.1 hypothetical protein -
IAP99_RS27275 24595..24810 + 216 WP_187726408.1 hypothetical protein -
IAP99_RS27280 24811..25014 + 204 WP_100027625.1 hypothetical protein -
IAP99_RS27285 25026..25331 + 306 WP_187726409.1 hypothetical protein -
IAP99_RS27290 25321..25554 + 234 WP_109949412.1 hypothetical protein -
IAP99_RS27295 25980..26141 + 162 WP_170982390.1 hypothetical protein -
IAP99_RS27300 26145..26282 + 138 WP_154674501.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..40436 40436


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(5-93)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-85)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11136.92 Da        Isoelectric Point: 10.1201

>T171034 WP_073535404.1 NZ_CP060809:c21234-20950 [Klebsiella variicola]
MTRKREIEYSGQFQKDVKKAQKRNKDMAKLKTLITLLIEDKLPLPAIYKDHPLQGDYKGYRDAHIEPDWLLIYKISDTKL
RFERTGTHSDLFKG

Download         Length: 285 bp

>T171034 NZ_CP077816:4921337-4921822 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCACAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9195.58 Da        Isoelectric Point: 5.0628

>AT171034 WP_073535405.1 NZ_CP060809:c21501-21241 [Klebsiella variicola]
MAANAFVRARIDEALKNEAADVLAGMGLTVSDLVRITLTKVAVEKALPFDMRIPNRTTAATIAASEKGVDVHRADDANDL
FEKLGI

Download         Length: 261 bp

>AT171034 NZ_CP077816:4921047-4921340 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H0EV41

Antitoxin

Source ID Structure
AlphaFold DB A0A7H0EV42

References