Detailed information of TA system TA171009

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): fst-RNAII/Fst(toxin)
• Location: 52220..52461
• Replicon: plasmid pSF2
• Accession: NZ_CP060802
• Organism: Enterococcus faecalis strain SF28073

Toxin (Protein)

• Gene name: fst
• Uniprot ID: -
• Locus tag: H9Q64_RS00810
• Protein ID: WP_002360667.1
• Coordinates: 52220..52330 (+)
• Length: 37 a.a.

Antitoxin (RNA)

Gene name	RNAII
Locus tag	-
Coordinates	52370..52461 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q64_RS00785	47823..48779	+	957	WP_000282655.1	thymidylate synthase	-
H9Q64_RS00790	48821..49306	+	486	WP_000175735.1	trimethoprim-resistant dihydrofolate reductase DfrC	-
H9Q64_RS00795	49316..49714	+	399	Protein_56	DegV family protein	-
H9Q64_RS00800	49770..50444	-	675	WP_001106022.1	IS6-like element IS257 family transposase	-
H9Q64_RS00805	50563..51499	-	937	Protein_58	replication initiator protein A	-
H9Q64_RS00810	52220..52330	+	111	WP_002360667.1	type I toxin-antitoxin system Fst family toxin	Toxin
-	52370..52461	-	92	NuclAT_0	-	Antitoxin
-	52370..52461	-	92	NuclAT_0	-	Antitoxin
-	52370..52461	-	92	NuclAT_0	-	Antitoxin
-	52370..52461	-	92	NuclAT_0	-	Antitoxin
H9Q64_RS00815	52570..52860	+	291	WP_001137528.1	hypothetical protein	-
H9Q64_RS00820	52964..53335	-	372	WP_000049959.1	replication-associated protein RepC	-
H9Q64_RS00825	53328..54173	-	846	WP_000239313.1	AAA family ATPase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	aac(6')-aph(2'') / qacD	-	1..54644	54644

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 37 a.a.
• Molecular weight: 4117.92 Da
• Isoelectric Point: 4.1672

>T171009 WP_002360667.1 NZ_CP060802:52220-52330 [Enterococcus faecalis]
VLFVKDLMSLVIAPIFVGLVLEMISRVLDEEDDNRK

Nucleotide

• Length: 111 bp

>T171009 NZ_CP077814:1633383-1634300 [Klebsiella pneumoniae]
ATGGATATACAGGCGCCTTATTATCGGCAGGTTGCTCTGCTAATGCAGGTTTTACCCTATGTTGCTGTCGAACGGGAATT
TGCGCTGAAAGGTGGCACTGCAATCAATCTCTTTATCCGCGATTTCCCTCGATTATCGGTGGATATCGACCTCGCCTGGG
TGCCCCTGGAAAGCAGAGCCATCGCTTTACCTCATATACGGGATGCGCTTGCACGTATTGCCGCCAATCTGCAACAACAG
GCAGGTATGAGCGCTGTATTACAAGCTAATCGTTCAGATGAGATGCGTGTCATTGTTACTACCGATAGCGCGCAAATAAA
GATAGAGGTTTCACCGGTCGCCCGGGGAACATTATATCCACCACAGGAGCGAGAAGTGGTGGGGGCGGTAGAGGACGTTT
TTGGCTATGCCAGCCTTCCAGTGGTTTCGTTGCCTGACCTCTACGGTGGAAAATTATGCGCGGCGCTGGATCGCCAGCAT
CCCAGAGATTTTTATGACGTGAAATTACTTCTTGATGCGCAGGAGCTTGACCGTCCCATTTTCAATGGGTTTATCGTGTA
TTTACTGAGCCATAATCGGCCTCTGGCTGAAGTGCTGAATCCTCGCTGGAAAGATATTGCTGAACCTTTTTACCGTGAAT
TCAGCGGGATGACATTTGAGACGATAGCCCTGGAGGAACTGACAGCAGTCCCCAACAGGATGATTGCTGCGTTAAAATCC
TGTATCACACAACAGGATGTCGATTTTTTACTGTCATTTAAACGAGGCGAACCAGACTGGCGTTTAGCGCCGGAAATGCG
TATTCAGGATTTGCCTGCCGTGCAGTGGAAATTGCGCAATATTCATCAGATGCCAGCGATAAAACGCGCTGAGTCATTAG
ATAAACTGGAAAAGGTGCTGGCCGAGTGGCGCAGTTAG

Antitoxin

Nucleotide

• Length: 92 bp

>AT171009 NZ_CP060802:c52461-52370 [Enterococcus faecalis]
TAAAAATATGTTATACTAAAGGTGCGAAACGACATTAAATCGTACAAATAACACAAAAAGCAATCCTACGGCGAATAGGA
TTGCTTTTTTTT

Structures

Antitoxin