Detailed information of TA system TA170998

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2654227..2654557
• Replicon: chromosome
• Accession: NZ_CP060796
• Organism: Enterococcus faecalis strain EF-2001

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: H8446_RS12975
• Protein ID: WP_002415596.1
• Coordinates: 2654227..2654370 (+)
• Length: 48 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2654303..2654557 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8446_RS12955	2649341..2649556	-	216	WP_002354768.1	zinc ribbon domain-containing protein	-
H8446_RS12960	2649695..2650687	+	993	WP_208777153.1	biotin--[acetyl-CoA-carboxylase] ligase	-
H8446_RS12965	2650951..2651589	-	639	WP_002378863.1	lytic polysaccharide monooxygenase	-
H8446_RS12970	2652277..2653893	+	1617	WP_010710855.1	phosphatase PAP2/LCP family protein	-
H8446_RS12975	2654227..2654370	+	144	WP_002415596.1	type I toxin-antitoxin system toxin PepG1	Toxin
-	2654303..2654557	-	255	-	-	Antitoxin
H8446_RS12980	2654559..2654942	-	384	Protein_2545	WxL domain-containing protein	-
H8446_RS12985	2654944..2656470	+	1527	Protein_2546	FAD-dependent oxidoreductase	-
H8446_RS12990	2656688..2657110	+	423	WP_002358956.1	NusG domain II-containing protein	-
H8446_RS12995	2657122..2657679	+	558	WP_002354743.1	Gx transporter family protein	-
H8446_RS13000	2657717..2658703	+	987	WP_002383156.1	polyprenyl synthetase family protein	-
-	2658773..2659085	+	313	NuclAT_0	-	-
-	2658773..2659085	+	313	NuclAT_0	-	-
-	2658773..2659085	+	313	NuclAT_0	-	-
-	2658773..2659085	+	313	NuclAT_0	-	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (14-47)

Sequences

Toxin

Protein

• Length: 48 a.a.
• Molecular weight: 5314.46 Da
• Isoelectric Point: 10.6323

>T170998 WP_002415596.1 NZ_CP060796:2654227-2654370 [Enterococcus faecalis]
MNVSAKIYERRGLLSAYETIQTILGFGMFTIALIALIVKLLKNDKKK

Nucleotide

• Length: 144 bp

>T170998 NZ_CP077812:c3310867-3310334 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCCAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGTATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 255 bp

>AT170998 NZ_CP060796:c2654557-2654303 [Enterococcus faecalis]
ATAAAAATGCCCGAGCCTTTAAATAGGAGGCTCAGGCATTTTTTATTGATGGTCTTTTTAGGGTTGTTGTGCTATAATGA
TAATGAAAAGAGAGGTATGCGACAACATACCTCTCTGGTGTAGAGCCGTTTAAGACGGTGACCGTGTTAATTATTTAAAA
ATAACCGTACTCAGTCAAAGTAGACGGTTATTTTTTCTTGTCATTTTTAAGCAATTTCACAATCAGTGCAATCAAAGCAA
TGGTAAACATACCAA

Structures

Antitoxin