Detailed information of TA system TA170993

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2574083..2574481
• Replicon: chromosome
• Accession: NZ_CP060796
• Organism: Enterococcus faecalis strain EF-2001

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: H8446_RS12625
• Protein ID: WP_023894767.1
• Coordinates: 2574083..2574187 (-)
• Length: 35 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2574327..2574481 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8446_RS12610	2569330..2570043	-	714	WP_002354877.1	trehalose operon repressor	-
H8446_RS12615	2570305..2573049	+	2745	WP_103557075.1	glycosyl hydrolase family 65 protein	-
H8446_RS12620	2573064..2573714	+	651	WP_077932659.1	beta-phosphoglucomutase	-
H8446_RS12625	2574083..2574187	-	105	WP_023894767.1	putative holin-like toxin	Toxin
-	2574327..2574481	+	155	-	-	Antitoxin
H8446_RS12630	2574980..2575513	+	534	WP_077932660.1	CPBP family intramembrane metalloprotease	-
H8446_RS12635	2575567..2576538	-	972	WP_002381060.1	ribose-phosphate diphosphokinase	-
H8446_RS12640	2576713..2577150	-	438	WP_002354871.1	peptide-methionine (R)-S-oxide reductase MsrB	-
H8446_RS12645	2577283..2577837	-	555	WP_002354869.1	Maf family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-34)

Sequences

Toxin

Protein

• Length: 35 a.a.
• Molecular weight: 3799.63 Da
• Isoelectric Point: 10.0079

>T170993 WP_023894767.1 NZ_CP060796:c2574187-2574083 [Enterococcus faecalis]
MSAYETIQTILGFGMFTIALIALIVKLLKNDNKK

Nucleotide

• Length: 105 bp

>T170993 NZ_CP077811:c45696-45214 [Klebsiella pneumoniae]
GTGGGATGTATAACTGCGCCCGAGCCGTTATCCAGCGCCCATCAACTGGCAGAGTTCGTCAGTGGGGAAACGGTACTCGA
TGAATGGTTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCACGAACTTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGCAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTTTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTTCACGATGCGGTTCTACGCTGTTATCGCGTAGCTGAGAATATTGGCGTTCGTGCGATAATGGTTCACGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCGCAAACTTATGAGCGGACTCTGTTCCTTAAACTTCCA
TGA

Antitoxin

Nucleotide

• Length: 155 bp

>AT170993 NZ_CP060796:2574327-2574481 [Enterococcus faecalis]
TTTTTAGGGAAATGTGCTATAATGAAAACGAAAAGAGAGATATGCGTCAACATACCTCTCTGATGTAGAACCGTTTAAGA
CGGTAACCATGTTAATTATTTAAAAATAACCGTGCTTGGTCAAAGTTGACGGTTATTTTTTATTGTCATTTTTAA

Structures

Antitoxin