Detailed information of TA system TA170982

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 2509283..2509507
• Replicon: chromosome
• Accession: NZ_CP060796
• Organism: Enterococcus faecalis strain EF-2001

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: H8446_RS12325
• Protein ID: WP_075551663.1
• Coordinates: 2509406..2509507 (-)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	2509283..2509461 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H8446_RS12300	2504930..2505883	-	954	WP_077932647.1	siderophore ABC transporter substrate-binding protein	-
H8446_RS12305	2505922..2506677	-	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
H8446_RS12310	2506674..2507639	-	966	WP_002371665.1	iron chelate uptake ABC transporter family permease subunit	-
H8446_RS12315	2507636..2508583	-	948	WP_002394759.1	iron chelate uptake ABC transporter family permease subunit	-
H8446_RS12320	2508768..2509220	+	453	WP_002359057.1	YueI family protein	-
-	2509283..2509461	+	179	-	-	Antitoxin
H8446_RS12325	2509406..2509507	-	102	WP_075551663.1	putative holin-like toxin	Toxin
H8446_RS12330	2509836..2509937	-	102	WP_224800345.1	putative holin-like toxin	-
H8446_RS12335	2510125..2512395	-	2271	WP_077932648.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
H8446_RS12340	2512566..2513066	+	501	WP_077932649.1	cysteine hydrolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T170982 WP_075551663.1 NZ_CP060796:c2509507-2509406 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T170982 NZ_CP077810:637972-638074 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 179 bp

>AT170982 NZ_CP060796:2509283-2509461 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCCTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTTATTGTTCTTTAACCGTTCAGCCGTCTAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCG
AAAATCAGTAACGCAACAA

Structures

Antitoxin