170976

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 573727..573959 Replicon chromosome
Accession NZ_CP060796
Organism Enterococcus faecalis strain EF-2001

Toxin (Protein)


Gene name txpA Uniprot ID C7CXQ5
Locus tag H8446_RS13765 Protein ID WP_002355568.1
Coordinates 573727..573843 (+) Length 39 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 573754..573959 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H8446_RS03035 569165..571423 + 2259 WP_002363179.1 DNA helicase PcrA -
H8446_RS03040 571549..573579 + 2031 WP_002355566.1 NAD-dependent DNA ligase LigA -
H8446_RS13765 573727..573843 + 117 WP_002355568.1 putative holin-like toxin Toxin
- 573754..573959 - 206 - - Antitoxin
H8446_RS03045 574161..574466 + 306 WP_002355569.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
H8446_RS03050 574466..575935 + 1470 WP_002355570.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
H8446_RS03055 575935..577365 + 1431 WP_002358703.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatB -
H8446_RS03060 577384..578472 + 1089 WP_002355572.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(3-35)


Sequences

Toxin        


Download         Length: 39 a.a.        Molecular weight: 4065.93 Da        Isoelectric Point: 5.9482

>T170976 WP_002355568.1 NZ_CP060796:573727-573843 [Enterococcus faecalis]
MFLSVEAALGLMIGFATLVVTIIFGILALVLDNKNNRS

Download         Length: 117 bp

>T170976 NZ_CP077809:c3373847-3373745 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 206 bp

>AT170976 NZ_CP060796:c573959-573754 [Enterococcus faecalis]
AAAAGAGAGATATGCAGGAACATACCTCTCTAATAGCCACTACTAGTTATAAGAACTAGCGGCTTACTGAGTTATTGGTT
TTATTTCAAACGCTTAACCGTTCAGCTCCTCAAAGCTTATGAACGGTTATTTTTGTTGTCTAAGACAAGCGCTAAGATAC
CGAAGATAATGGTCACAACAAGTGTTGCAAAACCAATCATCAGTCC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B4XLM6

Antitoxin

Download structure file

References