Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-VapI
Location 2022704..2023274 Replicon chromosome
Accession NZ_CP060789
Organism Tessaracoccus defluvii strain JCM 17540

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag H9L22_RS09800 Protein ID WP_187719760.1
Coordinates 2022993..2023274 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H9L22_RS09795 Protein ID WP_187719759.1
Coordinates 2022704..2023006 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9L22_RS09770 2018584..2019378 + 795 WP_187719755.1 hypothetical protein -
H9L22_RS09775 2019602..2020633 + 1032 WP_187722651.1 IS30 family transposase -
H9L22_RS09780 2020630..2021031 + 402 WP_187719756.1 GNAT family N-acetyltransferase -
H9L22_RS09785 2021479..2022027 - 549 WP_187719757.1 GNAT family N-acetyltransferase -
H9L22_RS09790 2022183..2022707 - 525 WP_187719758.1 GNAT family N-acetyltransferase -
H9L22_RS09795 2022704..2023006 - 303 WP_187719759.1 HigA family addiction module antidote protein Antitoxin
H9L22_RS09800 2022993..2023274 - 282 WP_187719760.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H9L22_RS09805 2023525..2025072 - 1548 WP_187719761.1 Abi family protein -
H9L22_RS09810 2025687..2026726 - 1040 Protein_1924 IS630 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2010612..2027988 17376
- flank IS/Tn - - 2025687..2026214 527


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(2-93)

Antitoxin

Cro/C1-type helix-turn-helix domain

(24-70)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10926.43 Da        Isoelectric Point: 9.8455

>T170964 WP_187719760.1 NZ_CP060789:c2023274-2022993 [Tessaracoccus defluvii]
VIRSFGDKATERLWRREPVRSIDPRIQRVALRKLRQVGSAERLDDLRIPPGNRLEALKGDRAGQYSIRINDQWRICFVWT
DAGPEEVEIVDYH

Download         Length: 282 bp

>T170964 NZ_CP077806:c3902016-3901633 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTTGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATAACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11002.60 Da        Isoelectric Point: 5.0747

>AT170964 WP_187719759.1 NZ_CP060789:c2023006-2022704 [Tessaracoccus defluvii]
MTITDKIPPIHPGEVLMEDFIEGFGITQNKLAVSIGVPPRRINEIVHGKRGITADTALRLAKYFGTSAEFWINLQSHYEL
DRAEDLAGEQIASITPLSVA

Download         Length: 303 bp

>AT170964 NZ_CP077806:c3902258-3902016 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References