Detailed information of TA system TA170962

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1089130..1089635
• Replicon: chromosome
• Accession: NZ_CP060789
• Organism: Tessaracoccus defluvii strain JCM 17540

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: H9L22_RS05115
• Protein ID: WP_182781594.1
• Coordinates: 1089130..1089396 (-)
• Length: 89 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: H9L22_RS05120
• Protein ID: WP_187721853.1
• Coordinates: 1089393..1089635 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9L22_RS05085	1084496..1085068	+	573	WP_187722572.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
H9L22_RS05090	1085065..1085991	+	927	WP_187721849.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	-
H9L22_RS05095	1086031..1086909	-	879	WP_187721850.1	DUF262 domain-containing protein	-
H9L22_RS05100	1086969..1087295	+	327	WP_187722789.1	hypothetical protein	-
H9L22_RS05105	1087882..1088064	+	183	WP_187721851.1	hypothetical protein	-
H9L22_RS05110	1088233..1088523	-	291	WP_187721852.1	hypothetical protein	-
H9L22_RS05115	1089130..1089396	-	267	WP_182781594.1	Txe/YoeB family addiction module toxin	Toxin
H9L22_RS05120	1089393..1089635	-	243	WP_187721853.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H9L22_RS05125	1089994..1090980	+	987	WP_187721854.1	hypothetical protein	-
H9L22_RS05130	1092487..1092750	-	264	WP_187721855.1	type II toxin-antitoxin system RelE/ParE family toxin	-
H9L22_RS05135	1092747..1093019	-	273	WP_187721856.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
H9L22_RS05140	1093003..1094145	-	1143	WP_187721857.1	site-specific integrase	-
H9L22_RS05145	1094207..1094539	-	333	WP_187721858.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1083654..1097164	13510

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 89 a.a.
• Molecular weight: 10240.83 Da
• Isoelectric Point: 9.7544

>T170962 WP_182781594.1 NZ_CP060789:c1089396-1089130 [Tessaracoccus defluvii]
VSPWTLVYSRQAQKDAQKLASSGLKTKAQHLLEVLAQDPFTTPPKYEKLVGDLAGCYSRRINIQHRLVYEVLPDRHVVHI
LRMWTHYE

Nucleotide

• Length: 267 bp

>T170962 NZ_CP077806:c3421455-3421171 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8705.62 Da
• Isoelectric Point: 3.9421

>AT170962 WP_187721853.1 NZ_CP060789:c1089635-1089393 [Tessaracoccus defluvii]
MTAVSATSARANLYRLIDQVNEESEPLTITGQRGNAVLIGEEDWLAIQETLFLESVPGLADSIRRSRAEGVDAGSTELDW

Nucleotide

• Length: 243 bp

>AT170962 NZ_CP077806:c3421687-3421445 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA