Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/YoeB-YefM
Location 1897184..1897686 Replicon chromosome
Accession NZ_CP060748
Organism Escherichia coli strain EC96

Toxin (Protein)


Gene name yoeB Uniprot ID U9YDH0
Locus tag IAI02_RS09055 Protein ID WP_000767829.1
Coordinates 1897432..1897686 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID S1Q063
Locus tag IAI02_RS09050 Protein ID WP_001259255.1
Coordinates 1897184..1897435 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IAI02_RS09025 1892362..1893429 - 1068 WP_097307568.1 bifunctional histidinol-phosphatase/imidazoleglycerol-phosphate dehydratase HisB -
IAI02_RS09030 1893429..1894499 - 1071 WP_097307567.1 histidinol-phosphate transaminase -
IAI02_RS09035 1894496..1895800 - 1305 WP_187476124.1 histidinol dehydrogenase -
IAI02_RS09040 1895806..1896705 - 900 WP_000131782.1 ATP phosphoribosyltransferase -
IAI02_RS09045 1896851..1896901 - 51 WP_001364200.1 his operon leader peptide -
IAI02_RS09050 1897184..1897435 + 252 WP_001259255.1 YoeB-YefM toxin-antitoxin system antitoxin YefM Antitoxin
IAI02_RS09055 1897432..1897686 + 255 WP_000767829.1 type II toxin-antitoxin system mRNA interferase toxin YoeB Toxin
IAI02_RS09060 1897769..1898593 + 825 WP_000754758.1 SDR family oxidoreductase -
IAI02_RS09065 1898639..1899568 + 930 WP_000803351.1 LysR family transcriptional regulator -
IAI02_RS09070 1899783..1899845 + 63 WP_010723108.1 membrane protein YoeI -
IAI02_RS09075 1899835..1901193 + 1359 WP_000019197.1 putrescine/proton symporter PlaP -
IAI02_RS09080 1901372..1902430 + 1059 WP_000492340.1 transport protein YeeE -
IAI02_RS09085 1902444..1902671 + 228 WP_000985273.1 sulfurtransferase TusA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(2-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10183.58 Da        Isoelectric Point: 8.0353

>T170938 WP_000767829.1 NZ_CP060748:1897432-1897686 [Escherichia coli]
VKLIWSEESWDDYLYWQETDKRIVKKINELIKDTRRTPFEGKGKPEPLKHNLSGFWSRRITEEHRLVYAVTDDSLLIAAC
RYHY

Download         Length: 255 bp

>T170938 NZ_CP077803:1254904-1255269 [Rhodospirillum rubrum]
ATGGTAGGCGCGCTTTTCGATACCAATATCCTCATCGATCATCTGAACGCCCGCCCCGAGGCTAGCGAGGAAATCGAGCG
ATTTGAGAGTCGCGCCATCAGCATCATCACATGGATGGAGGTGATGGTGGGCGCGCGCGCCGATCTGATAGAGCCGACCC
GGCTTTTTCTCGACGGCTTCAAAGTCATCGCATTGGACGACAAGATCGCCAAGCGCGCGGTGGACTTGCGGCGCGCCCAT
CGCATTAAACTGCCTGACGCGGTGATCTGGGCCACGGCGCAGACCACCGGACGCTTGCTTGTGACCCGCAACACCAAGGA
CTTTCCGCCCGACGATCCGGGGGTACGCGAACCCTACGCCTTGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9307.58 Da        Isoelectric Point: 4.7954

>AT170938 WP_001259255.1 NZ_CP060748:1897184-1897435 [Escherichia coli]
MRTISYSEARQNLSATMMKAVEDHAPILITRQNGEACVLMSLEEYNSLEETAYLLRSPANARRLMDSIDSLKSGKGTEKD
IIE

Download         Length: 252 bp

>AT170938 NZ_CP077803:1254695-1254910 [Rhodospirillum rubrum]
GTGAGAGCCCTTGTCGATATGAGCGATGCCCAGATCGAAGCCCTCGACACCCTTGCCAAGCGGGTGGGCCAGTCGCGTGC
CGCGCTGATCAGGGCGGCGATAGACGATTATCTAGATCGTCATCACCGCGAACAGGTCGCGGACGGTTTCGGCCTTTGGG
GCAAGCGCAAGGTCGATGGTCTGGCCTATCAGGAGAAGGCGCGCAGCGAATGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6NY6
PDB 2A6S
PDB 6OXA
PDB 2A6R
PDB 4V8X
PDB 6OTR
PDB 6OXI
PDB 2A6Q

Antitoxin

Source ID Structure
PDB 2A6Q
AlphaFold DB A0A7U9LNR0

References