170897

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1186402..1187051 Replicon chromosome
Accession NZ_CP060737
Organism Enterobacter roggenkampii isolate enterobacter cloacae

Toxin (Protein)


Gene name higB Uniprot ID A0A1S2AEP5
Locus tag H9W87_RS05515 Protein ID WP_045416590.1
Coordinates 1186689..1187051 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A1S2AD04
Locus tag H9W87_RS05510 Protein ID WP_047746098.1
Coordinates 1186402..1186701 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9W87_RS05500 1182826..1184799 + 1974 WP_047746094.1 PhoX family phosphatase -
H9W87_RS05505 1184903..1186291 + 1389 WP_047746095.1 phenylalanine transporter -
H9W87_RS05510 1186402..1186701 - 300 WP_047746098.1 helix-turn-helix transcriptional regulator Antitoxin
H9W87_RS05515 1186689..1187051 - 363 WP_045416590.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H9W87_RS05520 1187257..1188492 + 1236 WP_032663994.1 MFS transporter -
H9W87_RS05525 1188508..1189533 + 1026 WP_047746100.1 sugar phosphate isomerase/epimerase -
H9W87_RS05530 1189526..1190668 + 1143 WP_047746102.1 Gfo/Idh/MocA family oxidoreductase -
H9W87_RS05535 1190744..1191715 + 972 WP_021241589.1 LacI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1168601..1187051 18450


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(12-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(12-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13908.76 Da        Isoelectric Point: 5.1960

>T170897 WP_045416590.1 NZ_CP060737:c1187051-1186689 [Enterobacter roggenkampii]
MWNVETTDRFDDWFFEQTTALKEDVLATMHILAEFGPTLGRPYVDTVKDSAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCAGDKTGCNQKRFYNEMIALADVEYSRHLADKEAIWQR

Download         Length: 363 bp

>T170897 NZ_CP077770:896004-896942 [Pseudoalteromonas shioyasakiensis]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCTTTGCTCATAAGAATGCTGCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGTTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATAGTTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGGCAGTTCAAGAGTCTGTTGAATACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGGTTTCGAGAGAGATTTTAGTGGGTTTTTTAACCTA
TACATTAAGTCATCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCTCTGAATGAGAAATTTCAGGCAGAAT
TTGACGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCCTCTGTTAGGCCCATGATGTTAATTGAACTGCAAAAA
CATTTCACAGAAAGAGATCATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAATTGCAGAACATTAACAAATTGGCAAAGAATCAAGCAAAACACCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10906.70 Da        Isoelectric Point: 9.8627

>AT170897 WP_047746098.1 NZ_CP060737:c1186701-1186402 [Enterobacter roggenkampii]
MATLKELMAQQSAESQERIAAKVEVMRRIVALNQLREELNISQTELAAAMGVKQPTLAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Download         Length: 300 bp

>AT170897 NZ_CP077770:895220-896011 [Pseudoalteromonas shioyasakiensis]
ATGTCATCTAAGATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
TGTGAGCTATTCCTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTAAAGAAGCTATGTTCTGGCGTGTATTATCGTCCAG
ATGCGCGGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTAGATGTGCAATTGGGCGTTTCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTACAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAACAAGTCGTCCTTACCGAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGTGGAAACCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAACTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGATGCGATTGGAAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAACGAAGCAGCTCTGTTCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGGGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1S2AEP5

Antitoxin

Source ID Structure
AlphaFold DB A0A1S2AD04

References