Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3328129..3328822 Replicon chromosome
Accession NZ_CP060709
Organism Escherichia coli strain ST18

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag H9445_RS16420 Protein ID WP_000415584.1
Coordinates 3328526..3328822 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H9445_RS16415 Protein ID WP_000650107.1
Coordinates 3328129..3328524 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9445_RS16405 3323993..3326251 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
H9445_RS16410 3326389..3327996 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
H9445_RS16415 3328129..3328524 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H9445_RS16420 3328526..3328822 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
H9445_RS16425 3329027..3329509 - 483 WP_000183505.1 transcriptional regulator -
H9445_RS16430 3329562..3329954 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H9445_RS16435 3330106..3330765 + 660 WP_001221495.1 two-component system response regulator QseB -
H9445_RS16440 3330762..3332111 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
H9445_RS16445 3332157..3332489 - 333 WP_000917684.1 DUF2645 family protein -
H9445_RS16450 3332808..3333389 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
H9445_RS16455 3333420..3333734 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T170837 WP_000415584.1 NZ_CP060709:c3328822-3328526 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T170837 NZ_CP077717:1317424-1317798 [Saccharolobus shibatae B12]
TTGGCTAAATTTGTAACTAAGGAGAAAGGATGGGAGAAGATTACAGAGATTTTAAAAGACGCTGAGACATCAGACTTTGC
GTTAGTGGAAGTATCTAACGTAGTGTGGAAGAAAACCGTATTAACCAGAGAGTTAACTGAACAAGATGCAATTAAGGCAG
TTACTATAATCAGATACTATTTACCACAATTGCTGATATTGAATAAAAGTATTGACGTAATTGAAAGAGCTATTGAGATT
TCCATAAAAGAGAAAATCCCGATATATGATTCGCTTTATATCGCATTGGCTGAACGTAAAGGAAGTAAATTAGTAACTGG
GGATAGGAAGCAACACGAGATAGCGAAAAAGTACGTCATCTCAGAGCTTATATAG

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT170837 WP_000650107.1 NZ_CP060709:c3328524-3328129 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT170837 NZ_CP077717:1317192-1317413 [Saccharolobus shibatae B12]
ATGAAGACCGTATACAGTTTAAGGATAGATAAGGAATTACGTGAGGAGATGGAGAAATACAACGTTAAGTGGAATGAGGA
GATTGAGAACTTTATAAGGAGGAGGATTGAGGAGTTAAAGAAAGAGGAAATCTTCAAGAAGATTAATGAAATCCTCCAAA
CAATGCCCGAGACTAAGTCAAATAGTGCAGAATTGGTGAGGGAAGATAGGGATAATAGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References