Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mqsRA (relBE)/MqsR-MqsA |
Location | 3152583..3153276 | Replicon | chromosome |
Accession | NZ_CP060708 | ||
Organism | Escherichia coli strain MFDpir |
Toxin (Protein)
Gene name | mqsR | Uniprot ID | S1EZG2 |
Locus tag | H9446_RS15310 | Protein ID | WP_000415584.1 |
Coordinates | 3152980..3153276 (-) | Length | 99 a.a. |
Antitoxin (Protein)
Gene name | mqsA | Uniprot ID | S1EBV2 |
Locus tag | H9446_RS15305 | Protein ID | WP_000650107.1 |
Coordinates | 3152583..3152978 (-) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
H9446_RS15295 | 3148447..3150705 | - | 2259 | WP_001281881.1 | DNA topoisomerase IV subunit A | - |
H9446_RS15300 | 3150843..3152450 | - | 1608 | WP_001295629.1 | ABC transporter substrate-binding protein | - |
H9446_RS15305 | 3152583..3152978 | - | 396 | WP_000650107.1 | type II toxin-antitoxin system antitoxin MqsA | Antitoxin |
H9446_RS15310 | 3152980..3153276 | - | 297 | WP_000415584.1 | type II toxin-antitoxin system toxin MqsR | Toxin |
H9446_RS15315 | 3153481..3153963 | - | 483 | WP_000183505.1 | transcriptional regulator | - |
H9446_RS15320 | 3154016..3154408 | - | 393 | WP_000712658.1 | OB fold stress tolerance protein YgiW | - |
H9446_RS15325 | 3154560..3155219 | + | 660 | WP_001221495.1 | two-component system response regulator QseB | - |
H9446_RS15330 | 3155216..3156565 | + | 1350 | WP_000673402.1 | two-component system sensor histidine kinase QseC | - |
H9446_RS15335 | 3156611..3156943 | - | 333 | WP_000917684.1 | DUF2645 family protein | - |
H9446_RS15340 | 3157262..3157843 | + | 582 | WP_000065430.1 | NADPH:quinone oxidoreductase MdaB | - |
H9446_RS15345 | 3157874..3158188 | + | 315 | WP_000958598.1 | antibiotic biosynthesis monooxygenase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 99 a.a. Molecular weight: 11231.96 Da Isoelectric Point: 8.9070
>T170795 WP_000415584.1 NZ_CP060708:c3153276-3152980 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK
Download Length: 297 bp
>T170795 NZ_CP077706:2012574-2012677 [Salmonella enterica subsp. enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 132 a.a. Molecular weight: 14703.10 Da Isoelectric Point: 9.2136
>AT170795 WP_000650107.1 NZ_CP060708:c3152978-3152583 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR
Download Length: 396 bp
>AT170795 NZ_CP077706:c2012679-2012536 [Salmonella enterica subsp. enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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