Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 3152583..3153276 Replicon chromosome
Accession NZ_CP060708
Organism Escherichia coli strain MFDpir

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag H9446_RS15310 Protein ID WP_000415584.1
Coordinates 3152980..3153276 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag H9446_RS15305 Protein ID WP_000650107.1
Coordinates 3152583..3152978 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9446_RS15295 3148447..3150705 - 2259 WP_001281881.1 DNA topoisomerase IV subunit A -
H9446_RS15300 3150843..3152450 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
H9446_RS15305 3152583..3152978 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
H9446_RS15310 3152980..3153276 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
H9446_RS15315 3153481..3153963 - 483 WP_000183505.1 transcriptional regulator -
H9446_RS15320 3154016..3154408 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
H9446_RS15325 3154560..3155219 + 660 WP_001221495.1 two-component system response regulator QseB -
H9446_RS15330 3155216..3156565 + 1350 WP_000673402.1 two-component system sensor histidine kinase QseC -
H9446_RS15335 3156611..3156943 - 333 WP_000917684.1 DUF2645 family protein -
H9446_RS15340 3157262..3157843 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
H9446_RS15345 3157874..3158188 + 315 WP_000958598.1 antibiotic biosynthesis monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T170795 WP_000415584.1 NZ_CP060708:c3153276-3152980 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T170795 NZ_CP077706:2012574-2012677 [Salmonella enterica subsp. enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT170795 WP_000650107.1 NZ_CP060708:c3152978-3152583 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT170795 NZ_CP077706:c2012679-2012536 [Salmonella enterica subsp. enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References