Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/MqsA(antitoxin)
Location 1407147..1407799 Replicon plasmid Plas1
Accession NZ_CP060702
Organism Ralstonia solanacearum strain FJAT454.F50-1

Toxin (Protein)


Gene name higB Uniprot ID A0A454TTN3
Locus tag H9X76_RS24185 Protein ID WP_038962847.1
Coordinates 1407147..1407491 (+) Length 115 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag H9X76_RS24190 Protein ID WP_020425351.1
Coordinates 1407488..1407799 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H9X76_RS24170 1402843..1404006 - 1164 WP_016725329.1 2-methylcitrate synthase -
H9X76_RS24175 1404058..1404954 - 897 WP_038962849.1 methylisocitrate lyase -
H9X76_RS24180 1405147..1407096 + 1950 WP_023470006.1 propionate catabolism operon regulatory protein PrpR -
H9X76_RS24185 1407147..1407491 + 345 WP_038962847.1 hypothetical protein Toxin
H9X76_RS24190 1407488..1407799 + 312 WP_020425351.1 transcriptional regulator Antitoxin
H9X76_RS24195 1407938..1408743 - 806 Protein_1109 DUF2242 domain-containing protein -
H9X76_RS24200 1410716..1410717 - 2 WP_187810750.1 IS5 family transposase -
H9X76_RS24205 1411175..1412500 + 1326 WP_016725321.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - acrB / adeG / cheY / cheB / cheW / motA / cyaB / flgC / flgG / fliM / fliG / fliI 1..2074598 2074598


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(41-91)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13227.94 Da        Isoelectric Point: 8.4489

>T170749 WP_038962847.1 NZ_CP060702:1407147-1407491 [Ralstonia solanacearum]
MDATFIELPPFQRLREHYLSDDEYRALQQELLARPDAGDVIKGTGGLRKLRFSDKRRGKGKRGGLRVIDYHWDGGGQFWM
FVVYDKGEADDLSSDERKVLARLLEQEVKARSER

Download         Length: 345 bp

>T170749 NZ_CP077696:2029804-2029907 [Salmonella enterica subsp. enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11619.65 Da        Isoelectric Point: 10.7132

>AT170749 WP_020425351.1 NZ_CP060702:1407488-1407799 [Ralstonia solanacearum]
MKRNLFAELKEGMDALAAEREGKMTLRKVKVRVLQPLDVTAEEIKAVRAAAHASQAVMARRLRVNVRTYQNWEQGTAKPN
TQAAVLIKLVEKHPETLQMLEAL

Download         Length: 312 bp

>AT170749 NZ_CP077696:c2029909-2029766 [Salmonella enterica subsp. enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A454TTN3

Antitoxin

Source ID Structure

References