Detailed information of TA system TA170743

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/Txe-RelB
• Location: 1932397..1932968
• Replicon: chromosome
• Accession: NZ_CP060700
• Organism: Staphylococcus pseudintermedius strain cdc 18-1182

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: H9Q12_RS09190
• Protein ID: WP_187470716.1
• Coordinates: 1932397..1932711 (-)
• Length: 105 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: A0A3D8YKM0
• Locus tag: H9Q12_RS09195
• Protein ID: WP_014612814.1
• Coordinates: 1932711..1932968 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q12_RS12730	1927719..1928186	+	468	WP_206680120.1	hypothetical protein	-
H9Q12_RS12735	1929619..1929720	-	102	Protein_1783	KxYKxGKxW signal peptide domain-containing protein	-
H9Q12_RS09180	1930477..1931970	+	1494	WP_014612817.1	malate dehydrogenase (quinone)	-
H9Q12_RS09185	1931984..1932085	+	102	WP_019169745.1	DUF2648 domain-containing protein	-
H9Q12_RS09190	1932397..1932711	-	315	WP_187470716.1	Txe/YoeB family addiction module toxin	Toxin
H9Q12_RS09195	1932711..1932968	-	258	WP_014612814.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
H9Q12_RS09200	1933162..1935066	-	1905	WP_096533653.1	triacylglycerol lipase	-
H9Q12_RS09205	1935326..1935820	+	495	WP_015729749.1	membrane protein	-
H9Q12_RS09210	1936114..1936920	-	807	WP_187470717.1	arylamine N-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (25-77)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-68)

Sequences

Toxin

Protein

• Length: 105 a.a.
• Molecular weight: 12353.27 Da
• Isoelectric Point: 9.7293

>T170743 WP_187470716.1 NZ_CP060700:c1932711-1932397 [Staphylococcus pseudintermedius]
MGNYSVLIKNSAKNDLKKIKKSLLKEQFSKIIEVLKINPYEASQSFEKLQPKHSARYSRRLNHQHRVVYTVDDEKREVYI
FLLGHIMSERYVNKCCESIDSELY

Nucleotide

• Length: 315 bp

>T170743 NZ_CP077695:10806-11120 [Salmonella enterica subsp. enterica]
ATGCAGTTCACTGTATACAGTAACACCGGAAAGAGCACCGTCTATCCCCTGCTGCTTGATGTAACCAGCGATATTATCGG
CCAGTTGAACCGCAGGATTGTGATCCCGCTGCTGCCTGTTGAAAAGTACCCAGGCAGCACCCGCCCGGAACGGCTGGTTC
CGCTTGTCAGACTGACCGACGATAAAGAATATGCAGTTATGACGCATGAAATGGCGAGTATTCCCGCCCGTTCTCTGGGG
GCTGCGTTCTGCGATGCTTCCCCTTATCGTACCGAAGTCAAAGCTGCGATTGATTTTCTTCTTGATGGTATTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9866.87 Da
• Isoelectric Point: 4.1100

>AT170743 WP_014612814.1 NZ_CP060700:c1932968-1932711 [Staphylococcus pseudintermedius]
MIIKTPTNARKEFYELLKQVNDNHEPIIISGSKSENNAVIVSQEDWDSIQETLFLEYTGTMDKVRAREKDDSGYTNIDDI
DWDNL

Nucleotide

• Length: 258 bp

>AT170743 NZ_CP077695:10567-10803 [Salmonella enterica subsp. enterica]
ATGGCAACAACACAACGAGCAACGCAAAGCGTTACTATGACTGTAGAACGTGCCTTACTCAGCCGTGCGCGTGAGGCTGG
AATTAATCTCAGTGCCACTCTGACCGCAGCCCTTGACGCTGAACTACGCCAGTATGAAGCGAAAAAATGGCAGGAGGAAA
ACAACGAAGCGCTGGAAGCTCTTAATCGTTTTCACGATGAACATGGTTGTTTCAGCGATGAGTACAGGACATTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A3D8YKM0