Detailed information of TA system TA170737

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 173420..173931
• Replicon: chromosome
• Accession: NZ_CP060694
• Organism: Aliarcobacter cryaerophilus strain 16CS1292-4

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: -
• Locus tag: HOO33_RS00925
• Protein ID: WP_105925946.1
• Coordinates: 173668..173931 (+)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: HOO33_RS00920
• Protein ID: WP_187473050.1
• Coordinates: 173420..173671 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HOO33_RS00885	168799..169929	+	1131	WP_187473043.1	UDP-4-amino-4, 6-dideoxy-N-acetyl-beta-L-altrosamine transaminase	-
HOO33_RS00890	169922..170620	+	699	WP_187473044.1	pseudaminic acid cytidylyltransferase	-
HOO33_RS00895	170617..170895	+	279	WP_187473045.1	hypothetical protein	-
HOO33_RS00900	171072..171521	+	450	WP_187473046.1	hypothetical protein	-
HOO33_RS00905	171524..172555	+	1032	WP_187473047.1	pseudaminic acid synthase	-
HOO33_RS00910	172539..173066	+	528	WP_187473048.1	hypothetical protein	-
HOO33_RS00915	173077..173367	+	291	WP_187473049.1	hypothetical protein	-
HOO33_RS00920	173420..173671	+	252	WP_187473050.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
HOO33_RS00925	173668..173931	+	264	WP_105925946.1	Txe/YoeB family addiction module toxin	Toxin
HOO33_RS00930	173954..174655	+	702	WP_187473051.1	SDR family oxidoreductase	-
HOO33_RS00935	174655..175995	+	1341	WP_187473052.1	fatty acid--CoA ligase family protein	-
HOO33_RS00940	175992..176885	+	894	WP_187473053.1	hypothetical protein	-
HOO33_RS00945	176882..177946	+	1065	WP_187473054.1	aminotransferase class V-fold PLP-dependent enzyme	-
HOO33_RS00950	177950..178816	+	867	WP_187473055.1	methyltransferase domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-86)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-72)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10514.12 Da
• Isoelectric Point: 9.5799

>T170737 WP_105925946.1 NZ_CP060694:173668-173931 [Aliarcobacter cryaerophilus]
MIVGFSTKAWEDYKYWVQNDKQIVKRINLLLEDIKRNPYDSNGIGKPERLKENYSGYFSRRITSEHRLVYKIVDDLIIIA
QCRFHYL

Nucleotide

• Length: 264 bp

>T170737 NZ_CP077693:3854577-3854852 [Salmonella enterica subsp. enterica]
ATGAATGCCTCCGGCGTTAGCGTCCGCCATATCAACAGCGAAACCTGCATGACCGCCTGTTACTCACAAATCCCCAGCCA
GCACCTTAAGGGTGACTGGCAGGAAGAAGCGGGATTTGAGACCGGGCACGGCGTCACCGTGAAGATCTCCGAGGGGTGTT
TGATCCTGATTGCAGAGACGGACGAAGTGAGGGATCTACGGAAGGAGCTTTATCAGGTGAAAAAGTCGATGAAGCATATT
AAGGCGGGGGTAAATAATGTGGTGAACGGGGATTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9820.16 Da
• Isoelectric Point: 4.8278

>AT170737 WP_187473050.1 NZ_CP060694:173420-173671 [Aliarcobacter cryaerophilus]
MQVVQYSQARNNLREIINKVCDNFEEYIISTKDNKQAVLISQEEYNSMKETMYLLSSKANRDRLNEAIDEIENLKFIKKD
ISL

Nucleotide

• Length: 252 bp

>AT170737 NZ_CP077693:c3854842-3854420 [Salmonella enterica subsp. enterica]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTAACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT