Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 1182547..1183052 Replicon chromosome
Accession NZ_CP060693
Organism Aliarcobacter cryaerophilus strain 16CS1285-4

Toxin (Protein)


Gene name yoeB Uniprot ID -
Locus tag HOO34_RS06230 Protein ID WP_105915205.1
Coordinates 1182786..1183052 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A2S9T7Y9
Locus tag HOO34_RS06225 Protein ID WP_066161115.1
Coordinates 1182547..1182792 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
HOO34_RS06205 1177931..1178523 + 593 Protein_1208 DUF45 domain-containing protein -
HOO34_RS06210 1178525..1178965 - 441 WP_141052165.1 DUF721 domain-containing protein -
HOO34_RS06215 1179070..1180521 + 1452 WP_187473869.1 FAD-binding protein -
HOO34_RS06220 1180575..1182110 + 1536 WP_187473870.1 glutamine-hydrolyzing GMP synthase -
HOO34_RS06225 1182547..1182792 + 246 WP_066161115.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
HOO34_RS06230 1182786..1183052 + 267 WP_105915205.1 Txe/YoeB family addiction module toxin Toxin
HOO34_RS06235 1183062..1184765 - 1704 WP_187473871.1 YdiU family protein -
HOO34_RS06240 1184928..1186226 + 1299 WP_187473872.1 succinylglutamate desuccinylase/aspartoacylase family protein -
HOO34_RS06245 1186251..1186445 - 195 WP_105908832.1 DUF2892 domain-containing protein -
HOO34_RS06250 1186606..1187307 + 702 WP_187473873.1 alpha/beta hydrolase -
HOO34_RS06255 1187362..1187955 + 594 WP_187473874.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(3-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10202.94 Da        Isoelectric Point: 9.9946

>T170734 WP_105915205.1 NZ_CP060693:1182786-1183052 [Aliarcobacter cryaerophilus]
MVNYKLVYTKQAGKDAKKLSSSGLKSKALELLEIISLNPYQNPPPYEKLIGDLNSAISRRINIQHRLVYEVLEDIKTIKV
IRMWSHYE

Download         Length: 267 bp

>T170734 NZ_CP077693:2139309-2139412 [Salmonella enterica subsp. enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9257.54 Da        Isoelectric Point: 4.1220

>AT170734 WP_066161115.1 NZ_CP060693:1182547-1182792 [Aliarcobacter cryaerophilus]
MTKVMTVSQVRADIYNIIDETALTHEPILITGKRTNAVMLSQEDWNAIQETLYLTSIPNMRESIIKGLNTSIEDCDTELE
W

Download         Length: 246 bp

>AT170734 NZ_CP077693:c2139414-2139269 [Salmonella enterica subsp. enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2S9T7Y9

References