Detailed information of TA system TA170723

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2429821..2430046
• Replicon: chromosome
• Accession: NZ_CP060678
• Organism: Salmonella enterica strain 190610_1

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: H9Q82_RS11755
• Protein ID: WP_000813254.1
• Coordinates: 2429891..2430046 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2429821..2429879 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q82_RS11715	2424922..2425143	-	222	WP_000560208.1	cell division protein FtsZ	-
H9Q82_RS11720	2425581..2426102	+	522	WP_000004762.1	super-infection exclusion protein B	-
H9Q82_RS11725	2426210..2426365	-	156	WP_085981757.1	DUF1391 family protein	-
H9Q82_RS11730	2426750..2427217	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
H9Q82_RS11735	2427399..2427446	+	48	Protein_2273	hypothetical protein	-
H9Q82_RS11740	2427490..2427819	+	330	WP_001676916.1	DUF977 family protein	-
H9Q82_RS11745	2427981..2428535	-	555	WP_001033796.1	hypothetical protein	-
H9Q82_RS11750	2428532..2429464	-	933	WP_000556390.1	hypothetical protein	-
-	2429821..2429879	-	59	-	-	Antitoxin
H9Q82_RS11755	2429891..2430046	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
H9Q82_RS11760	2430337..2430507	+	171	WP_000734094.1	hypothetical protein	-
H9Q82_RS11765	2430570..2431169	+	600	WP_000940751.1	DUF1367 family protein	-
H9Q82_RS11770	2431169..2431459	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
H9Q82_RS11775	2431456..2431992	+	537	WP_000640113.1	DUF1133 family protein	-
H9Q82_RS11780	2434163..2434486	+	324	Protein_2282	tellurite/colicin resistance protein	-
H9Q82_RS11785	2434480..2434668	+	189	WP_001688615.1	putative holin	-
H9Q82_RS11790	2434658..2434939	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2400016..2435481	35465

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T170723 WP_000813254.1 NZ_CP060678:2429891-2430046 [Salmonella enterica]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T170723 NZ_CP077691:c2290229-2290047 [Salmonella enterica subsp. enterica]
ATGAAATATAACGAGTTCAGGCGGTGGCTCATCCAACAGGGTGCAAAGTTCATAAATGCACCGGATGGCGGCAGCCATCA
GCGTGTCATACTGAACGGGAAAGAATCTGTATTTCCCTGCCATGGCGCCAAAGAAATGCCGGAGCCGCTCAGAAAGAAAA
TACTCAAGGATTTGGGGCTTTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT170723 NZ_CP060678:c2429879-2429821 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin