Detailed information of TA system TA170706

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 384050..384652
• Replicon: chromosome
• Accession: NZ_CP060678
• Organism: Salmonella enterica strain 190610_1

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: H9Q82_RS01825
• Protein ID: WP_001159635.1
• Coordinates: 384050..384361 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: H9Q82_RS01830
• Protein ID: WP_000362050.1
• Coordinates: 384362..384652 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q82_RS01790 (379163)	379163..379762	+	600	WP_000965695.1	glucose-1-phosphatase	-
H9Q82_RS01795 (379756)	379756..380628	+	873	WP_000921423.1	virulence factor BrkB family protein	-
H9Q82_RS01800 (380625)	380625..381062	+	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
H9Q82_RS01805 (381107)	381107..382048	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
H9Q82_RS01810 (382063)	382063..382509	-	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
H9Q82_RS01815 (382506)	382506..382817	-	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
H9Q82_RS01820 (382903)	382903..383832	-	930	WP_001127705.1	alpha/beta hydrolase	-
H9Q82_RS01825 (384050)	384050..384361	+	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
H9Q82_RS01830 (384362)	384362..384652	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
H9Q82_RS01835 (384699)	384699..385628	-	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
H9Q82_RS01840 (385625)	385625..386260	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
H9Q82_RS01845 (386257)	386257..387159	-	903	WP_000331364.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T170706 WP_001159635.1 NZ_CP060678:384050-384361 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T170706 NZ_CP077680:c2421505-2421221 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGACTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAGTGACACGACACAGAAGCTAA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT170706 WP_000362050.1 NZ_CP060678:384362-384652 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT170706 NZ_CP077680:c2421743-2421495 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGCATTTCAAATTTTAACGACTACTGCAGCAAGCATTACAGAACTGAAACGTGACCCAATGGGAACTTTCAATGCCGG
AGATGGCGCTCCAGTTGCCATTCTTAACCGTAATGAACCGGCTTTCTACTGTGTGCCTCCGGCACTTTATGCTCATCTTA
TGGATATTCTTGAGGATGAAGAACTCGGTCGTATTATCGATGAGCGTGCGAATGAACGCGTCATTGAGGTCAACATTGAT
GACTTATAA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97