Detailed information of TA system TA170699

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 3239538..3240140
• Replicon: chromosome
• Accession: NZ_CP060676
• Organism: Salmonella enterica strain 190704_2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: M7S4R6
• Locus tag: H9Q83_RS16040
• Protein ID: WP_001159635.1
• Coordinates: 3239538..3239849 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: H9Q83_RS16045
• Protein ID: WP_000362050.1
• Coordinates: 3239850..3240140 (+)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q83_RS16005 (3234651)	3234651..3235250	+	600	WP_000965695.1	glucose-1-phosphatase	-
H9Q83_RS16010 (3235244)	3235244..3236116	+	873	WP_000921423.1	virulence factor BrkB family protein	-
H9Q83_RS16015 (3236113)	3236113..3236550	+	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
H9Q83_RS16020 (3236595)	3236595..3237536	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
H9Q83_RS16025 (3237551)	3237551..3237997	-	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	-
H9Q83_RS16030 (3237994)	3237994..3238305	-	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	-
H9Q83_RS16035 (3238391)	3238391..3239320	-	930	WP_001127705.1	alpha/beta hydrolase	-
H9Q83_RS16040 (3239538)	3239538..3239849	+	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	Toxin
H9Q83_RS16045 (3239850)	3239850..3240140	+	291	WP_000362050.1	DNA-binding transcriptional regulator	Antitoxin
H9Q83_RS16050 (3240187)	3240187..3241116	-	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
H9Q83_RS16055 (3241113)	3241113..3241748	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
H9Q83_RS16060 (3241745)	3241745..3242647	-	903	WP_000331364.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-85)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12340.30 Da
• Isoelectric Point: 9.4460

>T170699 WP_001159635.1 NZ_CP060676:3239538-3239849 [Salmonella enterica]
MQFIETELFTEDVKKLLDEDEYHKLQVFMAQHPDCGDVIQETGGLRKMRWGARGKGKRSGVRIIYFHRSQRYEIRLLLIY
QKGIKDDLTPQEKAVLRMLNERW

Nucleotide

• Length: 312 bp

>T170699 NZ_CP077679:c3772314-3772036 [Stenotrophomonas maltophilia]
ATGATCCGTTCATTCCGCTGCAAGCAGACCCGCGCTCTGTTTGAAGGAACCTGCCCCCGCGCCTGGCGCCCGATCCGGCG
GGCTGCTGAGCGCAAGCTGCAGTTGCTCGACTCGGCACAGACGTTGGCCTTCCTGCGCAGCCCGCCGGGAAACCGGCTGG
AGGCCCTGTCAGGTGATCGAAGGGGGCAATACAGCCTTCGCATCAACGATCAGTGGCGGCTCTGCTTCACCTGGACAGAC
AACGGTGCCGATGCCGTGGAAATTGTTGACTATCACTGA

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10971.59 Da
• Isoelectric Point: 10.6525

>AT170699 WP_000362050.1 NZ_CP060676:3239850-3240140 [Salmonella enterica]
MDKVLFERLTQSMSQMNEIIEGTREPSRTFHIDAMKIKEIRQASGLSQSKFAELISVNVDTLRNWEQGRRSPTGPAKALL
RAIANDPRNVIQALRY

Nucleotide

• Length: 291 bp

>AT170699 NZ_CP077679:c3772025-3771726 [Stenotrophomonas maltophilia]
ATGAAGCGTCCCTACAACGGCATGCGCGCCATCCATCCTGGCGAGGTCCTGCGCGAAGAGTTCCTGATACCGCTGGGGCT
GAGCGTGAACGCGCTGGCGAGGGCCCTGGATGTTCCCGCAACGCGGCTGCATGCCATCGTGCATGGCGAACGCGGCATTT
CGGCGGACACCGCCGCACGGCTGGCGCGCCATTTCGGTGGGGATGCCGCGTCCTGGCTTGCGATGCAGGCGGCCTACGAT
CTCAAGACCTTGCCAACGCGCAACGAGATTGAGCGCAGGGTGCAGCCGCGGGCGGCCTGA

Structures

Toxin

• AlphaFold DB: A0A3V2JK97