Detailed information of TA system TA170698

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 3237551..3238305
• Replicon: chromosome
• Accession: NZ_CP060676
• Organism: Salmonella enterica strain 190704_2

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5RFE2
• Locus tag: H9Q83_RS16030
• Protein ID: WP_000558168.1
• Coordinates: 3237994..3238305 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: H9Q83_RS16025
• Protein ID: WP_001259009.1
• Coordinates: 3237551..3237997 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q83_RS15995 (3232727)	3232727..3233623	+	897	WP_001520529.1	sugar kinase	-
H9Q83_RS16000 (3233657)	3233657..3234460	+	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
H9Q83_RS16005 (3234651)	3234651..3235250	+	600	WP_000965695.1	glucose-1-phosphatase	-
H9Q83_RS16010 (3235244)	3235244..3236116	+	873	WP_000921423.1	virulence factor BrkB family protein	-
H9Q83_RS16015 (3236113)	3236113..3236550	+	438	WP_000560968.1	D-aminoacyl-tRNA deacylase	-
H9Q83_RS16020 (3236595)	3236595..3237536	+	942	WP_001518251.1	fatty acid biosynthesis protein FabY	-
H9Q83_RS16025 (3237551)	3237551..3237997	-	447	WP_001259009.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
H9Q83_RS16030 (3237994)	3237994..3238305	-	312	WP_000558168.1	type II toxin-antitoxin system HigB family toxin	Toxin
H9Q83_RS16035 (3238391)	3238391..3239320	-	930	WP_001127705.1	alpha/beta hydrolase	-
H9Q83_RS16040 (3239538)	3239538..3239849	+	312	WP_001159635.1	cytotoxic translational repressor of toxin-antitoxin stability system	-
H9Q83_RS16045 (3239850)	3239850..3240140	+	291	WP_000362050.1	DNA-binding transcriptional regulator	-
H9Q83_RS16050 (3240187)	3240187..3241116	-	930	WP_000027736.1	formate dehydrogenase accessory protein FdhE	-
H9Q83_RS16055 (3241113)	3241113..3241748	-	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
H9Q83_RS16060 (3241745)	3241745..3242647	-	903	WP_000331364.1	formate dehydrogenase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12324.26 Da
• Isoelectric Point: 9.3143

>T170698 WP_000558168.1 NZ_CP060676:c3238305-3237994 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTLTQPEEMKRYIPSLDNFKHRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYDRGNKE

Nucleotide

• Length: 312 bp

>T170698 NZ_CP077679:c673835-672966 [Stenotrophomonas maltophilia]
GTGACCCACTCACCACCACTCCCCCAGCGCGTTGCTTCCATCCGGCAACGGCTGCTCGATCGCGCGCGCAGCCGAGGCGA
GGACTTTCAGTTCGTGCTGGACAGGTTCGCCGTTGAGCGCCTGCTCTACCGGCTCTCCACGTCCCGATACCGCGATCAGT
TCCTGCTGAAGGGCGCCATGTTTTTCGCCGTGTGGTTTGACATGCCCCATCGCCCCACACGCGATGCAGACTTTCTACGA
TTCGGCACTGCAGATCCCGACCATCTGCTGCACATCGTACGGTCGCTCTGCGCAATACCGGACGACGACGGCCTGTGCTT
CGACCCAGGCAGCATCGCCATCGAGGCCACCCGCGAAGAAGCGGAGTATGAGGGGCTGCGAATGCGCCTGACCGCACATC
TTGGCCGCTCGCGCTGCCACGTACAGTGGGACGTGGGGTTTGGCGATGCGGTGACTCCCCCACCGCAGGAAATCGCCTAC
CCGGTAATGCTGGATGACTTTCACGCACCCTTCCTGCGCGTCTATCCACGCGAGACCGTGTTTGCCGAAAAGCTGGAGGC
CATTGCGGCACTGGGCGTCGCCAACAGCAGGATGAAGGACTTCTTCGACTTGCTGGCACTGGTCCGCGAAGACGCAATGG
ATCGCCCGCACCTTGTTGCGGCCATTGGCGCGACGTTTGATCGACGAAGGACCCCGGCGCCGACGCCCTTGCCCTACGGA
CTGACTCAGTCGTTCGCCGCAGATACCCAGAAGCAGACCCAGTGGCGCGCCTTCCTGCGCAGGAATCGCCTGATCGCGCC
GGATCTCTCTTCGGTGATTGCCGAGATTGCCGAGTATCTGGACACCCTCGACACAACCGTACAGTCCTGA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16720.06 Da
• Isoelectric Point: 6.6451

>AT170698 WP_001259009.1 NZ_CP060676:c3237997-3237551 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKSVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT170698 NZ_CP077679:c674434-673832 [Stenotrophomonas maltophilia]
ATGGGAAACGCTGAGGCCAAGGCACGAAAGCTATTGCGACGCGCAGGCACCCTGCGCGCCCGCGAACTGGTGACCGCGGG
GATCGCCCGCACCCAACTGACCCGCCTGGTCGAGGCAGGTGCACTCATCCGGTTGTCCCGTGGCGTCTACACGTTGGCGG
AAAGAAACAGCGATGACACCGATGATGGGCTGCGGGTCATCGCAGAACGCCTGCCGCACCCCCGTCTATGCCTGTTGAGT
GCCCTGCGCCTGCATGGCCTGACCACCCAGGCGCCATTCGAACGCTGGGTCTCCATCGGCAACAGCGACCGCGCTCCGCG
GATCGATTGGCCGCCCCTTCGTGTGGTCCGCATGTCGGCAACGACCCTCAATTCGGGGCTGGAAGAACGTCGCGTAGGCA
GACGCCTCATATACGTCAGCAATGTAGCGAAAACCGTCGTCGATTGTTTCAAGTTCCGCAATCTCGTAGGACTTGATGTC
GCACTTGAAGCCCTGCGTGACGCGCTTCACAACCGTGCGACCACGCCGGATGCGCTGATGAAGTATGCGCGGATCTGTCG
CGTTGCCAGACTGATGAGACCGTACCTCGATGCCCTGGCGTGA

Structures

Toxin

• AlphaFold DB: A0A1R2S541