Detailed information of TA system TA170639

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2431244..2431469
• Replicon: chromosome
• Accession: NZ_CP060672
• Organism: Salmonella enterica strain 190729_8

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: H9Q85_RS11765
• Protein ID: WP_000813254.1
• Coordinates: 2431314..2431469 (+)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	2431244..2431302 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
H9Q85_RS11725	2426345..2426566	-	222	WP_000560208.1	cell division protein FtsZ	-
H9Q85_RS11730	2427004..2427525	+	522	WP_000004762.1	super-infection exclusion protein B	-
H9Q85_RS11735	2427633..2427788	-	156	WP_085981757.1	DUF1391 family protein	-
H9Q85_RS11740	2428173..2428640	-	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
H9Q85_RS11745	2428822..2428869	+	48	Protein_2275	hypothetical protein	-
H9Q85_RS11750	2428913..2429242	+	330	WP_001676916.1	DUF977 family protein	-
H9Q85_RS11755	2429404..2429958	-	555	WP_001033796.1	hypothetical protein	-
H9Q85_RS11760	2429955..2430887	-	933	WP_000556390.1	hypothetical protein	-
-	2431244..2431302	-	59	-	-	Antitoxin
H9Q85_RS11765	2431314..2431469	+	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
H9Q85_RS11770	2431760..2431930	+	171	WP_000734094.1	hypothetical protein	-
H9Q85_RS11775	2431993..2432592	+	600	WP_000940751.1	DUF1367 family protein	-
H9Q85_RS11780	2432592..2432882	+	291	WP_000774470.1	DUF1364 domain-containing protein	-
H9Q85_RS11785	2432879..2433415	+	537	WP_000640113.1	DUF1133 family protein	-
H9Q85_RS11790	2435586..2435909	+	324	Protein_2284	tellurite/colicin resistance protein	-
H9Q85_RS11795	2435903..2436091	+	189	WP_001688615.1	putative holin	-
H9Q85_RS11800	2436081..2436362	+	282	WP_000445513.1	phage holin family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2401439..2436904	35465

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T170639 WP_000813254.1 NZ_CP060672:2431314-2431469 [Salmonella enterica]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T170639 NZ_CP077662:c4336263-4335772 [Salmonella enterica]
ATGATCTCCCCCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGCCACTGGTGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCGCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATCCCGATTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGAACCATCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT170639 NZ_CP060672:c2431302-2431244 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin